Four of these compounds are used as probes to evaluate enzyme activity in the so-called “Cooperstown cocktail.” Assays for these compounds often calculate their SSMD before subjecting them to QSAR modeling. The acronym ADME describes the kinetics of these compounds, (10[1])which are characterized by Lipinski’s rule of five. Cytochrome P450 monooxygenases modify these compounds in the first phase of their metabolism. (10[1])The first-pass effect reduces the bioavailability (10[1])of these compounds. (10[3])High-throughput screening is used in the “discovery” of these compounds, whose potency (10[1])is given by the EC50. These compounds must pass Phase III clinical trials before receiving regulatory (10[2])approval by the (10[1])FDA. For 10 points, name (10[1])these compounds studied in pharmacology. ■END■