Four of these compounds are used as probes to evaluate enzyme activity in the so-called “Cooperstown cocktail.” Assays for these compounds often calculate their SSMD before subjecting them to QSAR modeling. The acronym ADME describes the kinetics of these compounds, which are characterized by Lipinski’s rule of five. Cytochrome P450 monooxygenases modify these compounds in the first phase of their metabolism. The first-pass effect reduces the bioavailability (10[1])of these compounds. High-throughput screening is used in the “discovery” of these compounds, whose (10[1])potency is given by the EC50. These compounds must pass Phase III clinical trials before receiving regulatory (10[1])approval (10[1])by the (10[1])FDA. (10[1])For 10 points, name these (-5[1])compounds studied in pharmacology. ■END■ (10[2])