Four of these compounds are used as probes to evaluate enzyme activity in the so-called “Cooperstown cocktail.” Assays for these compounds often calculate their SSMD before subjecting them to QSAR modeling. The acronym ADME (-5[1])describes (10[1])the kinetics of these compounds, (10[2])which are (10[1])characterized by Lipinski’s rule of five. (10[7])Cytochrome (10[1])P450 monooxygenases (-5[1])modify these compounds (10[1])in the first phase of their metabolism. (10[3])The (10[1])first-pass effect reduces the bioavailability (10[4])of these compounds. (10[3]-5[1])High-throughput screening is used in the “discovery” of these compounds, (10[2])whose (10[1])potency (10[1])is given by the EC50. (10[1]-5[1])These compounds must pass Phase III clinical trials (10[2])before receiving (10[1]-5[1])regulatory (10[6])approval (10[2]-5[1])by the (10[2])FDA. (10[3])For 10 points, name (10[1])these (-5[1])compounds (10[1])studied in (10[1])pharmacology. (10[2])■END■ (10[8])