Four of these compounds are used as probes to evaluate enzyme activity in the so-called “Cooperstown cocktail.” Assays for these compounds often calculate their SSMD before subjecting them to QSAR modeling. The acronym ADME (-5[1])describes the kinetics of these compounds, which are characterized by Lipinski’s rule of five. (10[1])Cytochrome P450 monooxygenases modify these compounds in the first phase of their metabolism. The first-pass effect reduces the bioavailability of these compounds. (-5[1])High-throughput screening is used in the “discovery” of these compounds, (10[1])whose potency is given by the EC50. (10[1])These compounds must pass Phase III clinical trials (10[1])before receiving regulatory (10[1])approval by the FDA. For 10 points, name these compounds studied in pharmacology. ■END■ (10[3])