Four of these compounds are used as probes to evaluate enzyme activity in the so-called “Cooperstown cocktail.” Assays for these compounds often calculate their SSMD before subjecting them to QSAR modeling. The acronym ADME describes the kinetics of these compounds, which are (10[1])characterized by Lipinski’s rule of five. Cytochrome (10[1])P450 monooxygenases modify these compounds in the first phase of their metabolism. The first-pass effect reduces the bioavailability (10[1])of these compounds. High-throughput screening is used in the “discovery” of these compounds, (10[1])whose potency is given by the EC50. These compounds must pass Phase III clinical trials before receiving (-5[1])regulatory (10[1])approval (10[1])by the FDA. (10[1])For 10 points, name these compounds (10[1])studied in pharmacology. ■END■ (10[2])