Question

K. Barry Sharpless won the 2022 Nobel Prize in Chemistry for “the development of click chemistry.” Answer some questions about click reactions, for 10 points each.
[10h] This motif is the most ring-strained nitrogen heterocycle, making ring-opening reactions involving these rings efficient and therefore describable as “click.”
ANSWER: aziridine
[10e] Electron-deficient rings like epoxides and aziridines can frequently be opened by these reactive chemical species that are typically basic and negatively charged. These species “attack” electrophiles.
ANSWER: nucleophiles [accept Nuc]
[10m] Another click chemistry reaction is this reaction, in which nucleophiles attack alpha-beta-unsaturated ketones or other namesake “acceptors.”
ANSWER: Michael addition [or Michael reaction; accept Michael 1,4-addition; prompt on 1,4-conjugate addition]
<JZ, Chemistry>

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FarrellmagnetismArizona State010010
MSU A and FriendBoston College010010