Question
K. Barry Sharpless won the 2022 Nobel Prize in Chemistry for “the development of click chemistry.” Answer some questions about click reactions, for 10 points each.
[10h] This motif is the most ring-strained nitrogen heterocycle, making ring-opening reactions involving these rings efficient and thus describable as “click.”
ANSWER: aziridine
[10e] Electron-deficient rings like epoxides and aziridines can frequently be opened by these reactive chemical species that are typically basic and negatively charged. These species “attack” electrophiles.
ANSWER: nucleophiles [accept Nuc]
[10m] Another click chemistry reaction is this reaction where namesake “acceptors” are attacked by nucleophiles. Acceptors in this reaction include alpha-beta-unsaturated ketones.
ANSWER: Michael addition [or Michael reaction; accept Michael 1,4-addition; prompt on 1,4-conjugate addition]
<JZ, Chemistry>
Summary
| 2023 ARCADIA at UC Berkeley | Premiere | Y | 2 | 15.00 | 100% | 50% | 0% |
| 2023 ARCADIA at Carleton University | Premiere | Y | 3 | 6.67 | 67% | 0% | 0% |
| 2023 ARCADIA at Claremont Colleges | Premiere | Y | 1 | 0.00 | 0% | 0% | 0% |
| 2023 ARCADIA at Indiana | Premiere | Y | 5 | 10.00 | 60% | 20% | 20% |
| 2023 ARCADIA at RIT | Premiere | Y | 2 | 15.00 | 100% | 50% | 0% |
| 2023 ARCADIA at WUSTL | Premiere | Y | 3 | 13.33 | 100% | 33% | 0% |
Data
| Missouri A | Missouri B | 0 | 10 | 0 | 10 |
| SIUE | Squidward Community College | 0 | 10 | 0 | 10 |
| WUSTL XYZ | WUSTL H2O | 0 | 10 | 10 | 20 |