Question
K. Barry Sharpless won the 2022 Nobel Prize in Chemistry for “the development of click chemistry.” Answer some questions about click reactions, for 10 points each.
[10h] This motif is the most ring-strained nitrogen heterocycle, making ring-opening reactions involving these rings efficient and therefore describable as “click.”
ANSWER: aziridine
[10e] Electron-deficient rings like epoxides and aziridines can frequently be opened by these reactive chemical species that are typically basic and negatively charged. These species “attack” electrophiles.
ANSWER: nucleophiles [accept Nuc]
[10m] Another click chemistry reaction is this reaction, in which nucleophiles attack alpha-beta-unsaturated ketones or other namesake “acceptors.”
ANSWER: Michael addition [or Michael reaction; accept Michael 1,4-addition; prompt on 1,4-conjugate addition]
<JZ, Chemistry>
Summary
| 2023 ARCADIA at Duke | Emory, Duke, Yale | Y | 4 | 5.00 | 50% | 0% | 0% |
| 2023 ARCADIA at Emory | Emory, Duke, Yale | Y | 3 | 20.00 | 67% | 67% | 67% |
| 2023 ARCADIA at Imperial | Imperial | Y | 5 | 8.00 | 80% | 0% | 0% |
| 2023 ARCADIA at Maryland | Maryland, Online | Y | 4 | 5.00 | 25% | 0% | 25% |
| 2023 ARCADIA at Ohio State | Ohio State, Texas | Y | 3 | 6.67 | 67% | 0% | 0% |
| 2023 ARCADIA Online | Maryland, Online | Y | 2 | 10.00 | 100% | 0% | 0% |
| 2023 ARCADIA at Texas | Ohio State, Texas | Y | 3 | 6.67 | 67% | 0% | 0% |
Data
| Johns Hopkins | George Washington A | 0 | 10 | 0 | 10 |
| George Washington B | Georgetown | 0 | 0 | 0 | 0 |
| George Washington A | Georgetown | 10 | 0 | 0 | 10 |
| Maryland A | Maryland B | 0 | 0 | 0 | 0 |