Question

K. Barry Sharpless won the 2022 Nobel Prize in Chemistry for “the development of click chemistry.” Answer some questions about click reactions, for 10 points each.
[10h] This motif is the most ring-strained nitrogen heterocycle, making ring-opening reactions involving these rings efficient and thus describable as “click.”
ANSWER: aziridine
[10e] Electron-deficient rings like epoxides and aziridines can frequently be opened by these reactive chemical species that are typically basic and negatively charged. These species “attack” electrophiles.
ANSWER: nucleophiles [accept Nuc]
[10m] Another click chemistry reaction is this reaction where namesake “acceptors” are attacked by nucleophiles. Acceptors in this reaction include alpha-beta-unsaturated ketones.
ANSWER: Michael addition [or Michael reaction; accept Michael 1,4-addition; prompt on 1,4-conjugate addition]
<JZ, Chemistry>

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Summary

2023 ARCADIA at UC BerkeleyPremiereY215.00100%50%0%
2023 ARCADIA at Carleton UniversityPremiereY36.6767%0%0%
2023 ARCADIA at Claremont CollegesPremiereY10.000%0%0%
2023 ARCADIA at IndianaPremiereY510.0060%20%20%
2023 ARCADIA at RITPremiereY215.00100%50%0%
2023 ARCADIA at WUSTLPremiereY313.33100%33%0%

Data

Stanford ABerkeley A010010
Berkeley BBerkeley C0101020