Question

PSD4/RPN-10 binds to this protein by expressing the LALAL (“L-A-L-A-L”) motif. This protein’s activity can be promoted by incorporating the DCAF (“decaf”) receptor into a “molecular glue” for recruitment of the CUL4-DDB1 (“cull-four D-D-B-one”) complex. This protein’s ability to bind to a substrate is enhanced by a complex composed of Skp1, Cullin, and F-box subunits. Proximity-promoted addition of this protein to other molecules can be facilitated by PROTACs. About 4 monomers of protein must be attached by lysine linkages before its primary function is (10[1])carried out. A series of 3 ligases (10[1])add this protein to other proteins to mark them for degradation in the 26S (10[1])proteasome. (10[2])For 10 points, name this 76-amino acid “molecular kiss of death” whose name derives from its expression in nearly all eukaryotic cells. ■END■ (10[1])

ANSWER: ubiquitin [or ubiquitination; or Ub; accept ubiquitin ligases]
<Biology>
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Buzzes

PlayerTeamOpponentBuzz PositionValue
Russell NipUBC AClaremont A7910
Ryan HumphreyTexas ASorbonne8610
Aswath KaraiMichigan State AAppalachian State10010
Dimitris KalafatisTexas A&M BUW A10110
Deepak MuthyalaTexas A&M AIowa B10110
Kathy LiangRice AIowa A12410