Question

PSD4/RPN-10 binds to this protein by expressing the LALAL (“L-A-L-A-L”) motif. This protein’s activity can be promoted by incorporating the DCAF (“decaf”) receptor into a “molecular glue” for recruitment of the CUL4-DDB1 (10[1])(“cull-four D-D-B-one”) complex. This protein’s ability to bind to a substrate is enhanced by a complex composed of Skp1, (10[1])Cullin, and F-box (-5[1])subunits. (10[1]-5[1])Proximity-promoted addition of this protein (10[2])to other (10[1])molecules can be facilitated by PROTACs. About (10[1])4 (10[1])monomers of protein must be attached by lysine (10[1])linkages before its primary function is (10[1])carried out. A series of 3 ligases (10[1])add (10[1])this protein to other proteins (10[1])to mark them (10[1])for degradation (10[2])in the (10[1]-5[1])26S (10[3])proteasome. (10[2])For 10 points, (10[1])name this 76-amino acid “molecular kiss (10[1])of death” whose name derives from its expression in nearly all (10[2])eukaryotic (10[3])cells. ■END■ (10[7]0[3])

ANSWER: ubiquitin [or ubiquitination; or Ub; accept ubiquitin ligases]
<Biology>
= Average correct buzz position

Buzzes

PlayerTeamOpponentBuzz PositionValue
Oscar DespardCambridge ACambridge B2910
Enoch YuenImperial AEdinburgh4610
Vishal Kanigcherla (UG)PennNYU B49-5
David BassJohns HopkinsColumbia C5010
Saketh Dontaraju (DII)NYU AHaverford50-5
Allan LeeStanford CBerkeley B5510
Geoffrey Wu (UG)Columbia ARowan5510
Ted WarnerBristolKiel5710
Alexander HarmataMichigan AOhio State A6410
Sam MooreDurham AImperial B6510
Rasheeq Azad (UG)UNC B (UG)Duke A (UG)7310
Russell NipUBC AClaremont A7910
Ryan HumphreyTexas ASorbonne8610
Munir Siddiqui (UG)Maryland B (UG)UNC A (Grad)8710
Vinu HariharBerkeley CBerkeley A9210
Iris Pardue (UG)KenyonCedarville9510
Natan HoltzmanStanford BStanford A9710
Amogh KulkarniGeodesicKentucky9710
Zander Werner (DII)Virginia C (UG)William & Mary A (UG)99-5
Rohan DalalGeorgia Tech BGeorgia Tech A9910
Aswath KaraiMichigan State AAppalachian State10010
Sam Macchi (DII)VassarJohn Jay10010
Bryanna ShaoVanderbilt AAlabama10010
Deepak MuthyalaTexas A&M AIowa B10110
Dimitris KalafatisTexas A&M BUW A10110
Jacob RobertsonOxford AWarwick10410
Vedang Singhal (DII)UNC D (DII)Virginia B (UG)11010
Kenny Zhang (UG)Virginia A (UG)GWU B (Grad)12110
Alexander BakerOxford BDurham B12110
Yared TadesseCornell ACornell B12210
Isaac Mammel (UG)Maryland A (Grad)JMU B (UG)12210
Jack ObermanSouth CarolinaHarding12210
Cade ReinbergerRIT BBinghamton12410
Michael Eng (UG)UNC C (UG)Liberty B (DII)1240
Andrew Amygdalos (UG)GWU A (UG)Maryland C (DII)1240
Brian Dudley (UG)William & Mary A (UG)Virginia C (UG)12410
Kathy LiangRice AIowa A12410
Mitchell IndekMichigan CMichigan B12410
Dennis Yang (DII)Michigan BMichigan C1240
Arjun Bothra (UG)HaverfordNYU A12410
Andrew FisherSheffieldKCL12410
Linus LuuCambridge COxford C12410