Question

PSD4/RPN-10 binds to this protein by expressing the LALAL (“L-A-L-A-L”) motif. This protein’s activity can be promoted by incorporating the DCAF (“decaf”) receptor into a “molecular glue” for recruitment of the CUL4-DDB1 (10[1])(“cull-four D-D-B-one”) complex. This protein’s ability to bind to a substrate is enhanced by a complex composed of Skp1, (10[1])Cullin, and F-box subunits. Proximity-promoted addition of this protein to other (10[1])molecules can be facilitated by PROTACs. About 4 (10[1])monomers of protein must be attached by lysine linkages before its primary function is carried out. A series of 3 ligases add this protein to other proteins to mark them for degradation in the 26S proteasome. For 10 points, (10[1])name this 76-amino acid “molecular kiss of death” whose name derives from its expression in nearly all (10[1])eukaryotic cells. ■END■ (10[2])

ANSWER: ubiquitin [or ubiquitination; or Ub; accept ubiquitin ligases]
<Biology>
= Average correct buzz position

Back to tossups

Buzzes

PlayerTeamOpponentBuzz PositionValue
Oscar DespardCambridge ACambridge B2910
Enoch YuenImperial AEdinburgh4610
Ted WarnerBristolKiel5710
Sam MooreDurham AImperial B6510
Jacob RobertsonOxford AWarwick10410
Alexander BakerOxford BDurham B12110
Linus LuuCambridge COxford C12410
Andrew FisherSheffieldKCL12410