Question

PSD4/RPN-10 binds to this protein by expressing the LALAL (“L-A-L-A-L”) motif. This protein’s activity can be promoted by incorporating the DCAF (“decaf”) receptor into a “molecular glue” for recruitment of the CUL4-DDB1 (“cull-four D-D-B-one”) complex. This protein’s ability to bind to a substrate is enhanced by a complex composed of Skp1, Cullin, and F-box subunits. Proximity-promoted addition of this protein to other molecules can be facilitated by PROTACs. About 4 monomers of protein must be attached by lysine (10[1])linkages before its primary function is carried out. A series of 3 ligases add (10[1])this protein to other proteins to mark them for degradation in the (-5[1])26S proteasome. For 10 points, name this 76-amino acid “molecular kiss (10[1])of death” whose name derives from its expression in nearly all (10[1])eukaryotic (10[1])cells. ■END■ (10[1]0[2])

ANSWER: ubiquitin [or ubiquitination; or Ub; accept ubiquitin ligases]
<Biology>
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Buzzes

PlayerTeamOpponentBuzz PositionValue
Rasheeq Azad (UG)UNC B (UG)Duke A (UG)7310
Munir Siddiqui (UG)Maryland B (UG)UNC A (Grad)8710
Zander Werner (DII)Virginia C (UG)William & Mary A (UG)99-5
Vedang Singhal (DII)UNC D (DII)Virginia B (UG)11010
Kenny Zhang (UG)Virginia A (UG)GWU B (Grad)12110
Isaac Mammel (UG)Maryland A (Grad)JMU B (UG)12210
Andrew Amygdalos (UG)GWU A (UG)Maryland C (DII)1240
Michael Eng (UG)UNC C (UG)Liberty B (DII)1240
Brian Dudley (UG)William & Mary A (UG)Virginia C (UG)12410