Question

One isoform of this enzyme requires lysyl-tRNA-3 to bind to a PBS before it can bind its substrate. Drugs that competitively inhibit this enzyme are normally given in pairs like tenofovir alafen·amide-emtrici·tabine. In certain “foamy” organisms, this enzyme is uniquely synthesized from a separate mRNA strand rather than a Gag precursor. The forced copy choice and the dynamic choice models describe a process that compensates for this enzyme’s high error rate and (15[1])is called (*) template switching. An RNAse H domain is present on this enzyme which, along with a protease and integrase, are transcribed from the (10[1])pol gene. Gene expression is frequently measured using a variant of PCR reliant on this enzyme’s ability to generate cDNA. For 10 points, name this central dogma-violating enzyme that allows retroviruses like HIV to produce DNA from an RNA template. ■END■

ANSWER: reverse transcriptase [or RT]
<HK, Biology>
= Average correct buzz position

Back to tossups

Buzzes

PlayerTeamOpponentBuzz PositionValue
Shahar SchwartzBerkeley ABerkeley C7115
Rohan ShelkeBerkeley BStanford A9510

Summary

2023 ARCADIA at UC BerkeleyPremiereY2100%50%0%83.00
2023 ARCADIA at Carleton UniversityPremiereY367%33%0%80.50
2023 ARCADIA at Claremont CollegesPremiereY10%0%100%0.00
2023 ARCADIA at IndianaPremiereY580%20%40%101.75
2023 ARCADIA at RITPremiereY250%0%100%136.00
2023 ARCADIA at WUSTLPremiereY3100%33%0%86.00