Question

SAR405 regulates this process by inhibiting Vps34, which activates a protein complex containing MLST8 and PRAS40. HSC70 initiates one form of this (10[1])process by binding to proteins with a KFERQ (“K-F-E-R-Q”) motif and directing them to a LAMP2A multimeric complex. That chaperone-mediated form of this process is important for regulating cells under mechanical stress like muscle cells. By phosphorylating ULK1, mTOR (“M-tor”) downregulates this process. A study of this process earned Yoshinori (10[1])Ohsumi a Nobel Prize in 2016. In yeast, this process is regulated by ATG proteins, and may be induced via starvation. (-5[1])During this process, large vesicles bind to lysosomes, whose hydrolytic enzymes break down defective proteins and organelles. (-5[1])For 10 points, name this process in which a cell digests (10[1])its own components. ■END■ (10[4]0[4])

ANSWER: autophagy [or autophagocytosis; reject “phagocytosis”]
<Ohio State A, Biology>
= Average correct buzz position

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Summary

California2025-02-01Y367%0%100%111.50
Florida2025-02-01Y250%0%50%122.00
Lower Mid-Atlantic2025-02-01Y650%0%67%114.33
Midwest2025-02-01Y683%0%50%92.40
North2025-02-01Y333%0%100%122.00
Northeast2025-02-01Y560%0%20%106.33
Overflow2025-02-01Y580%0%60%86.75
South Central2025-02-01Y2100%0%0%96.00
Southeast2025-02-01Y475%0%50%104.33
UK2025-02-01Y1070%0%20%99.43
Upper Mid-Atlantic2025-02-01Y850%0%75%110.25
Upstate NY2025-02-01Y333%0%67%120.00

Buzzes

PlayerTeamOpponentBuzz PositionValue
Oscar DespardCambridge ACambridge E2110
Arya KarthikOxford ASouthampton A6910
Andy HuffLSEOxford C90-5
Jaz the MononymousSouthampton BManchester107-5
Arvin BoraghiCambridge CWarwick A11810
James ByrneBristolCambridge D12210
Kai MadgwickManchesterSouthampton B1220
Justin LeeImperial ANYU C12210
Hamish CampbellDurhamOxford B12210
Freddy PottsSheffieldImperial B1220
Joseph CollinsImperial BSheffield1220
Percy YuenCambridge DBristol1220
Shiv SeshanCambridge BWarwick B12210