SAR405 regulates this process by inhibiting Vps34, which activates a protein complex containing MLST8 and PRAS40. HSC70 initiates one form of this (10[1])process (-5[2])by binding to proteins with a KFERQ (“K-F-E-R-Q”) motif and directing them (10[1])to a LAMP2A (-5[1])multimeric complex. That chaperone-mediated (10[1])form of this (-5[1])process (-5[3])is important for regulating cells under (-5[1])mechanical stress like muscle cells. (-5[1])By phosphorylating ULK1, mTOR (10[1])(“M-tor”) downregulates this process. A study of this process earned Yoshinori (10[2])Ohsumi (10[2])a Nobel Prize in 2016. (10[2])In yeast, this process is regulated by ATG proteins, and may be induced via starvation. (-5[3])During this (-5[1])process, (-5[4])large vesicles (-5[1])bind to lysosomes, (-5[3])whose (10[1])hydrolytic enzymes (10[1]-5[1])break (-5[1])down defective proteins and organelles. (-5[1])For 10 points, (-5[1])name this process (-5[1])in which a cell digests (10[1]-5[2])its (-5[1])own (10[2]-5[1])components. (10[1])■END■ (10[20]0[21])