Question
SAR405 regulates this process by inhibiting Vps34, which activates a protein complex containing MLST8 and PRAS40. HSC70 initiates one form of this process by binding to proteins with a KFERQ (“K-F-E-R-Q”) motif and directing them to a LAMP2A multimeric complex. That chaperone-mediated form of this process is important for regulating cells under mechanical stress like muscle cells. By phosphorylating ULK1, mTOR (“M-tor”) downregulates this process. A study of this process earned Yoshinori Ohsumi a Nobel Prize in 2016. In yeast, this process is regulated by ATG proteins, and may be induced via starvation. During this process, large vesicles bind to lysosomes, whose hydrolytic enzymes break down defective proteins and organelles. For 10 points, name this process in which a cell digests its own components. ■END■
ANSWER: autophagy [or autophagocytosis; reject “phagocytosis”]
<Ohio State A, Biology>
= Average correct buzz position
Summary
| California | 2025-02-01 | Y | 3 | 67% | 0% | 100% | 111.50 |
| Florida | 2025-02-01 | Y | 2 | 50% | 0% | 50% | 122.00 |
| Lower Mid-Atlantic | 2025-02-01 | Y | 6 | 50% | 0% | 67% | 114.33 |
| Midwest | 2025-02-01 | Y | 6 | 83% | 0% | 50% | 92.40 |
| North | 2025-02-01 | Y | 3 | 33% | 0% | 100% | 122.00 |
| Northeast | 2025-02-01 | Y | 5 | 60% | 0% | 20% | 106.33 |
| Overflow | 2025-02-01 | Y | 5 | 80% | 0% | 60% | 86.75 |
| South Central | 2025-02-01 | Y | 2 | 100% | 0% | 0% | 96.00 |
| Southeast | 2025-02-01 | Y | 4 | 75% | 0% | 50% | 104.33 |
| UK | 2025-02-01 | Y | 10 | 70% | 0% | 20% | 99.43 |
| Upper Mid-Atlantic | 2025-02-01 | Y | 8 | 50% | 0% | 75% | 110.25 |
| Upstate NY | 2025-02-01 | Y | 3 | 33% | 0% | 67% | 120.00 |
Buzzes
| Player | Team | Opponent | Buzz Position | Value |
|---|---|---|---|---|
| Oscar Despard | Cambridge A | Cambridge E | 21 | 10 |
| Jacob Egol | Duke | Virginia Tech A | 22 | -5 |
| Rohan Dalal | Georgia Tech C | Georgia Tech A | 22 | -5 |
| Stan Melkumian | Purdue | Georgetown B | 33 | 10 |
| Vikshar Athreya | Rutgers A | George Washington A | 36 | -5 |
| Collin Nadarajah | WashU A | Missoui S&T | 40 | 10 |
| June Yin | WashU B | Missouri | 43 | -5 |
| Bill Zhao | Florida B | Valencia A | 44 | -5 |
| Michał Gerasimiuk | Stanford B | Notre Dame A | 44 | -5 |
| Sinecio Morales | Johns Hopkins A | Vassar A | 44 | -5 |
| Braeden LaRoche | South Carolina | Virginia A | 50 | -5 |
| Jiping Fang | Illinois C | Chicago C | 55 | -5 |
| Adam Fine | Chicago A | Illinois A | 59 | 10 |
| Jack Lewis | Bruin A | Georgia Tech D | 69 | 10 |
| Arya Karthik | Oxford A | Southampton A | 69 | 10 |
| Sharath Narayan | Northwestern A | Notre Dame C | 70 | 10 |
| Bryan Ugaz | ASU | TAMU | 70 | 10 |
| Jonathan Huang | MIT A | Tufts A | 75 | 10 |
| Noah Chen | Columbia B | NYU A | 75 | 10 |
| Nithin Mendu | Wisconsin A | Iowa State | 90 | -5 |
| Harris Beckner | Alabama A | Louisville A | 90 | -5 |
| Andy Huff | LSE | Oxford C | 90 | -5 |
| Pranaav Senthilkumar | Cornell D | Binghamton A | 92 | -5 |
| Swapnil Garg | UC Berkeley A | UC Berkeley B | 93 | -5 |
| Scarlet Rutter | Claremont B | Claremont A | 93 | -5 |
| Aaron Marchand | Carleton | Minnesota B | 93 | -5 |
| Will Hoover | RIT A | ESF A | 93 | -5 |
| William Parocai | Dartmouth A | Brown A | 95 | -5 |
| Michael Eng | UNC C | Liberty C | 98 | -5 |
| Ian Saylor | Wisconsin B | Winona State | 98 | -5 |
| Arjun Bothra | Haverford A | Columbia C | 98 | -5 |
| Rasheeq Azad | UNC B | Liberty B | 99 | 10 |
| Kevin Park | Claremont A | Claremont B | 101 | 10 |
| Jerry Vinokurov | John Jay College | Maryland A | 101 | -5 |
| Alex Akridge | Indiana A | Indiana B | 102 | -5 |
| Jaz the Mononymous | Southampton B | Manchester | 107 | -5 |
| Leonard Castine | Penn B | George Washington B | 110 | -5 |
| Rachel Ezrielev | Georgetown A | Iowa | 113 | -5 |
| Terrence Han | UCLA | UCSD | 118 | -5 |
| Arvin Boraghi | Cambridge C | Warwick A | 118 | 10 |
| Anirudh Bharadwaj | Penn A | Maryland B | 118 | -5 |
| Stephen Walsh | Northwestern B | Notre Dame B | 119 | -5 |
| Aidan Jones | Liberty A | Wake Forest | 120 | -5 |
| Yash Mandavia | Illinois B | Chicago D | 120 | 10 |
| Alec Riso | Cornell C | RIT B | 120 | 10 |
| Samarth Ram | Chicago C | Illinois C | 121 | 10 |
| Vinu Harihar | UC Berkeley B | UC Berkeley A | 122 | 10 |
| Clete Reinberger | Valencia A | Florida B | 122 | 0 |
| Tiffany Zhou | Florida A | Florida State A | 122 | 10 |
| Nick Smemoe | UNC D | William & Mary | 122 | 0 |
| Audrey Read | Liberty C | UNC C | 122 | 0 |
| Meredie Cohen | William & Mary | UNC D | 122 | 0 |
| Ilyas Choukri | Virginia Tech A | Duke | 122 | 10 |
| Joseph Chambers | Virginia A | South Carolina | 122 | 10 |
| Trenton Burgess | Indiana B | Indiana A | 122 | 0 |
| Braden Booth | Missouri | WashU B | 122 | 10 |
| Conor Thompson | Iowa State | Wisconsin A | 122 | 0 |
| Henry Bon | Winona State | Wisconsin B | 122 | 10 |
| Eren Michelet | BU | UMass Boston | 122 | 0 |
| Max Neal | Harvard B | Brandeis B | 122 | 0 |
| Jon Suh | Harvard A | Brandeis A | 122 | 10 |
| Mason Yu | Brown A | Dartmouth A | 122 | 10 |
| Ben Koberlein | Notre Dame B | Northwestern B | 122 | 0 |
| Jacob Finley | Notre Dame A | Stanford B | 122 | 10 |
| Brielle Rach | Iowa | Georgetown A | 122 | 10 |
| Karan Gurazada | Texas A | Texas B | 122 | 10 |
| Tianyu Xu | Georgia Tech A | Georgia Tech C | 122 | 10 |
| Brina Ratangee | Vanderbilt A | Tennessee A | 122 | 10 |
| Parker McCoig | Tennessee A | Vanderbilt A | 122 | 0 |
| James Byrne | Bristol | Cambridge D | 122 | 10 |
| Kai Madgwick | Manchester | Southampton B | 122 | 0 |
| Justin Lee | Imperial A | NYU C | 122 | 10 |
| Hamish Campbell | Durham | Oxford B | 122 | 10 |
| Freddy Potts | Sheffield | Imperial B | 122 | 0 |
| Joseph Collins | Imperial B | Sheffield | 122 | 0 |
| Percy Yuen | Cambridge D | Bristol | 122 | 0 |
| Shiv Seshan | Cambridge B | Warwick B | 122 | 10 |
| Derek Chen | Columbia C | Haverford A | 122 | 10 |
| Andy Yu | Maryland A | John Jay College | 122 | 10 |
| Zaid Asif | NYU B | Yale A | 122 | 10 |
| Alexandria Wyers | George Washington A | Rutgers A | 122 | 0 |
| Sam Macchi | Vassar A | Johns Hopkins A | 122 | 0 |
| Frederick Rivas-Giorgi | Yale A | NYU B | 122 | 0 |
| Ian Parsons | Maryland B | Penn A | 122 | 0 |
| Peter Lutz | George Washington B | Penn B | 122 | 0 |
| Gregory Stone | ESF A | RIT A | 122 | 0 |
| Giuseppe Piccirilli | Binghamton A | Cornell D | 122 | 0 |