To study this disease, the Karmanos Institute at Wayne State University derived the MCF7 and MCF10A cell lines. Classification of this disease can be done using the Nottingham index or BI-RADS. A particularly aggressive form of this disease presents with an “orange peel” appearance from pressure on Cooper’s ligaments. It’s not related to bones, but Paget’s disease often indicates an underlying case of this disease, which may involve dissection of the axillary lymph nodes and can be treated with SERMs like tamoxifen. The absence of HER2, (10[1])estrogen, and progesterone receptors (10[1])characterize the “triple negative” form of this disease. Susceptibility to this disease is increased by mutations in two genes named for it called BRCA (“bra-ka”) 1 and 2. For 10 points, name this type of cancer screened for by a mammogram. ■END■