Question

Mutations in BLM proteins involved in fixing the start of this process can lead to Bloom’s syndrome. During this process, one type of structure is produced in either “short” or “long” pathways depending on FEN1 (“fen-one”) activity. CDC7 and Dbf4 begin this process by phosphorylating the MCM complex. John Cairns experimented (10[1])on theta structures that form during this process, which uses an enzyme that can be cleaved to form the Klenow fragment. The trimeric PCNA sliding clamp increases the processivity of an enzyme involved in this process. In this semiconservative (10[1])process, Okazaki (10[2])fragments on the lagging strand are fixed by ligase. (10[1])This process occurs in the S phase of the cell cycle. For 10 points, name this first process of the central dogma, in which the genetic material of a cell is copied. ■END■

ANSWER: DNA replication [accept DNA synthesis]
<Toronto D, Biology>
= Average correct buzz position

Back to tossups

Buzzes

PlayerTeamOpponentBuzz PositionValue
Jonathan HuangMIT ABrandeis A4910
Mason YuBrown ABU8810
Jerry ZhangHarvard BHarvard A9010
William ParocaiDartmouth ATufts A9010
Michael SunBrandeis BUMass Boston9910

Summary

California2025-02-01Y367%0%33%68.00
Florida2025-02-01Y3100%0%0%89.00
Great Lakes2025-02-01Y6100%0%0%87.33
Lower Mid-Atlantic2025-02-01Y683%0%33%87.80
Midwest2025-02-01Y6100%0%0%63.00
North2025-02-01Y3100%0%0%94.67
Northeast2025-02-01Y5100%0%0%83.20
Pacific Northwest2025-02-01Y250%0%100%132.00
South Central2025-02-01Y2100%0%50%89.00
Southeast2025-02-01Y4100%0%0%90.25
Upper Mid-Atlantic2025-02-01Y989%0%22%97.75
Upstate NY2025-02-01Y3100%0%33%103.67