GPCRs - 2025 Penn Bowl - UK

Question

One of these proteins from the T1R family possesses a VFT module that can close around glutamate. During homologous desensitization, examples of these proteins with phosphorylated tails are targeted for endocytosis after being bound to beta-arrestin. Robert Lefkowitz and Brian Kobilka were awarded a Nobel Prize for their research on one of these proteins that binds to epinephrine. Retinal acts as a chromophore in many light-sensitive kinds of these proteins (15[2]-5[1])named (*) opsins. A heterotrimeric complex induces adenylyl cyclase to synthesize cAMP following activation (-5[1])of one of these proteins. These proteins characteristically contain seven transmembrane alpha-helical regions. For 10 points, name these (-5[1])proteins that operate in conjunction with G-proteins to initiate signal transduction. ■END■ (10[1]0[10])

ANSWER: GPCRs [or G-protein coupled receptors; accept 7TM receptors or seven-transmembrane domain receptors until “seven” is read; prompt on beta-adrenergic receptors with “what family of proteins are they a member of?”; prompt on opsins or rhodopsins until “opsins” is read with “what family of proteins are they a member of?”; prompt on receptor proteins until “receptor” is read; reject “G-proteins”]

= Average correct buzz position

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Summary


2025 Penn Bowl - Stanford	10/25/25	Y	4	100%	50%	50%	71.75
2025 Penn Bowl - Northwestern	10/25/25	Y	4	50%	50%	50%	36.00
2025 Penn Bowl - Mainsite (UPenn)	11/01/25	Y	6	50%	17%	67%	75.33
2025 Penn Bowl - BU	11/01/25	Y	4	50%	25%	25%	63.50
2025 Penn Bowl - CWRU	11/01/25	Y	3	67%	0%	67%	99.50
2025 Penn Bowl - UNC	11/01/25	Y	2	50%	50%	50%	57.00
2025 Penn Bowl - WashU	11/01/25	Y	2	100%	50%	0%	56.50
2025 Penn Bowl - Ottawa	11/01/25	Y	7	43%	14%	43%	78.67
2025 Penn Bowl - UK	11/01/25	Y	9	33%	22%	33%	83.33
2025 Penn Bowl - Online	11/08/25	Y	2	50%	0%	50%	112.00
2025 Penn Bowl - Murray State	11/08/25	Y	2	0%	0%	100%	0.00

Buzzes

Player	Team	Opponent	Buzz Position	Value
Ted Warner	Bristold	Alas poor Warwick, I knew him Edinburgh	69	15
Vivek Sasse	Hail to the Sheaf	Coughing Baby	69	15
Nathan Easow	why is it called a score clue if nobody scores points on it	Quiztian Bale in Ratman Begins	69	-5
Ewan MacAulay	Washed Scrubs	Knorr Stock Clue	82	-5
Daoud Jackson	To buzz is to be perceived	Penn and the Art of Tossup-Bonus cycle Maintenance	100	-5
Charlie Lowman	Paul Quifford, or, It Was a Dark and Stormy Tournament	1. Wawa 2. Blank Street 151. Black Sheep at Kings Cross rail	112	0
Zach Foster	1. Wawa 2. Blank Street 151. Black Sheep at Kings Cross rail	Paul Quifford, or, It Was a Dark and Stormy Tournament	112	0
Oscar O’Flanagan	Chimp Brisket	Burnaburiash's Lapis Lazuli	112	0
Max Fitz-James	Burnaburiash's Lapis Lazuli	Chimp Brisket	112	0
Sam Moore	Knorr Stock Clue	Washed Scrubs	112	10
Omer Keskin	Penn and the Art of Tossup-Bonus cycle Maintenance	To buzz is to be perceived	112	0
Gus Redding	The Bit and the Penndulum	Galactic Ombudsmen	112	0
Oliver West	Galactic Ombudsmen	The Bit and the Penndulum	112	0
Andrei Hui	question mark	Of Mice and Penn	112	0
Dillon Patel	Of Mice and Penn	question mark	112	0
Philip Jordan	Quiztian Bale in Ratman Begins	why is it called a score clue if nobody scores points on it	112	0