GPCRs - 2025 Penn Bowl - Ottawa

Question

One of these proteins from the T1R family possesses a VFT module that can close around glutamate. During homologous desensitization, examples of these proteins with phosphorylated tails are targeted for endocytosis after being bound to beta-arrestin. Robert Lefkowitz (15[1])and Brian Kobilka were awarded a Nobel Prize for their research on one of these proteins that binds to epinephrine. Retinal acts as a chromophore in many light-sensitive kinds of these proteins named (*) opsins. A heterotrimeric (-5[1])complex induces adenylyl cyclase to synthesize cAMP following activation of one of these (-5[1])proteins. (10[1])These proteins characteristically contain seven transmembrane alpha-helical regions. For 10 points, name these proteins that operate in conjunction with G-proteins to (-5[1])initiate signal transduction. ■END■ (10[1]0[5])

ANSWER: GPCRs [or G-protein coupled receptors; accept 7TM receptors or seven-transmembrane domain receptors until “seven” is read; prompt on beta-adrenergic receptors with “what family of proteins are they a member of?”; prompt on opsins or rhodopsins until “opsins” is read with “what family of proteins are they a member of?”; prompt on receptor proteins until “receptor” is read; reject “G-proteins”]

= Average correct buzz position

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Summary


2025 Penn Bowl - Stanford	10/25/25	Y	4	100%	50%	50%	71.75
2025 Penn Bowl - Northwestern	10/25/25	Y	4	50%	50%	50%	36.00
2025 Penn Bowl - Mainsite (UPenn)	11/01/25	Y	6	50%	17%	67%	75.33
2025 Penn Bowl - BU	11/01/25	Y	4	50%	25%	25%	63.50
2025 Penn Bowl - CWRU	11/01/25	Y	3	67%	0%	67%	99.50
2025 Penn Bowl - UNC	11/01/25	Y	2	50%	50%	50%	57.00
2025 Penn Bowl - WashU	11/01/25	Y	2	100%	50%	0%	56.50
2025 Penn Bowl - Ottawa	11/01/25	Y	7	43%	14%	43%	78.67
2025 Penn Bowl - UK	11/01/25	Y	9	33%	22%	33%	83.33
2025 Penn Bowl - Online	11/08/25	Y	2	50%	0%	50%	112.00
2025 Penn Bowl - Murray State	11/08/25	Y	2	0%	0%	100%	0.00

Buzzes

Player	Team	Opponent	Buzz Position	Value
Jason Zhang	Toronto Operation PBSuccess	Queen's is monitoring the situation	37	15
Maude-Sophie Lockman	Aweille Kevin Fan osti continue comme ça	McGill B	73	-5
Victor Xu	Toronto E	McGill Fartlets	86	-5
Tony Chen	Toronto G	Guelph perfomative male competition	87	10
Halee Carey	Ottawa 67s	Toronto Sunshine Bubbles	108	-5
Jesse Chusing	#OpenToBuzz	Carleton A	112	0
Nicolaus Derikx	Carleton A	#OpenToBuzz	112	0
Ava Butler	McGill B	Aweille Kevin Fan osti continue comme ça	112	0
Charlie Ruff	McGill Fartlets	Toronto E	112	0
Caleb Ott	Waterloo you are crooked	Toronto Murder on the Rider Express	112	10
Sean Gao	Toronto Sunshine Bubbles	Ottawa 67s	112	0