One ruler with this name was deemed a heretic after the mystic Catherine of Siena declared her “demonically misguided” for failing to back Urban VI. After her husband Andrew was thrown from a window (15[1])with a rope tied to his genitals, that ruler of this name faced annexation (15[1])by her brother-in-law, Louis the Great of Hungary. To absolve herself of murder charges, that ruler of this name sold (*) Avignon to the papacy for 80,000 florins. Both queens regnant of Naples had this first name, (10[2])as well as a ruler that was confined to the Palace of Tordesillas (-5[1])after the death of her (10[2])husband, Philip the Handsome. That ruler of this name was deemed mentally unfit to rule by her father Ferdinand II, leading to the ascension of her son Charles V. For 10 points, give this name of a Spanish queen with the epithet “The Mad.” (-5[1])■END■ (10[1]0[2])