One ruler with this name was deemed a heretic after the mystic Catherine of Siena declared her “demonically misguided” for failing to back Urban VI. After her husband Andrew was thrown from a window with a rope tied to his genitals, that ruler of this name faced annexation by her brother-in-law, Louis the Great of Hungary. To absolve herself of murder charges, that ruler of this name sold (*) Avignon to the papacy for 80,000 florins. Both queens regnant of Naples had this first name, as well as a ruler that was confined to the Palace of Tordesillas after the death of her husband, Philip the Handsome. (10[1])That (-5[1])ruler of this name was deemed mentally unfit (10[1])to rule by her father Ferdinand II, leading to the ascension (10[1])of her son Charles V. For 10 points, give this name of a Spanish queen with the epithet “The Mad.” ■END■