Sapienic acid inhibits microbial growth in this organ, where it’s produced by Propionibacteria-mediated degradation of triglycerides. Increased porphyrin production in this organ due to Vitamin B12 supplementation is associated (-5[1])with a condition sometimes treated with tetracyclines. KOH (“k-o-h”) dissolves cells from this organ to yield a “spaghetti and meatballs” appearance in a positive test for Malassezia. Filaggrin mutations make this organ more susceptible to colonization by reducing the integrity of (*) corneocytes. Comedones (“kah-muh-DOH-neez”) form in this non-pancreatic organ, whose resident dendritic cells are Langerhans (10[1])cells. (-5[2])Along with mucous membranes, Staph aureus naturally colonizes this organ, where it processes apocrine gland secretions and sebum. For 10 points, name this organ where microbes and hyperkeratinization cause acne. (10[1])■END■ (10[3])