Sapienic acid inhibits microbial growth in this organ, where it’s produced by Propionibacteria-mediated degradation of triglycerides. Increased porphyrin production in this organ due to Vitamin B12 supplementation is associated with a condition sometimes treated with tetracyclines. KOH (“k-o-h”) dissolves cells from this organ to yield a “spaghetti and meatballs” appearance in a positive test for Malassezia. Filaggrin mutations make this organ more susceptible to colonization by reducing the integrity of (*) corneocytes. Comedones (“kah-muh-DOH-neez”) form in this non-pancreatic organ, whose (10[1])resident dendritic cells are Langerhans (-5[1])cells. (-5[2])Along (-5[1])with mucous membranes, Staph aureus naturally colonizes this organ, where it processes apocrine gland secretions and sebum. For 10 points, name this organ where microbes and hyperkeratinization cause acne. (10[1])■END■ (10[3])