Sapienic acid inhibits microbial growth in this organ, where it’s produced by Propionibacteria-mediated degradation of triglycerides. Increased porphyrin production in this organ due to Vitamin B12 supplementation is associated with a condition sometimes treated with tetracyclines. KOH (“k-o-h”) dissolves cells from this organ to yield a “spaghetti and meatballs” appearance in a positive test for Malassezia. Filaggrin mutations make this organ more susceptible to colonization by reducing the integrity of (*) corneocytes. Comedones (“kah-muh-DOH-neez”) form in this non-pancreatic organ, whose resident dendritic cells are Langerhans (10[1])cells. Along with mucous membranes, Staph aureus naturally colonizes this organ, where it processes apocrine gland secretions and sebum. For 10 points, (10[1])name this organ where microbes and hyperkeratinization cause acne. ■END■