proteins - 2024 ACF Winter at UBC

Question

Structural information about these molecules is stored in the legacy .pdb file format, which can be used in molecular docking simulations of their interactions. For 10 points each:

[10m] Name these molecules that are designated as “bait” and “prey” in the two-hybrid assay to identify interactions between them. These molecules are often fragmented when sequenced via tandem mass spectrometry.

ANSWER: proteins [accept Protein Data Bank; accept protein–protein interactions; prompt on polypeptides]

[10e] Protein–protein interactions are in part driven by these dipole–dipole interactions between electronegative atoms and the lightest element.

ANSWER: hydrogen bonds [or hydrogen bonding or H-bonds or H-bonding]

[10h] A protein’s interactome can be found by fusing it with the promiscuous ligase BirA, which attaches this molecule to binding partners. Those partners are then purified for mass spec sequencing using this molecule’s high affinity for streptavidin.

ANSWER: biotin [or vitamin B7 or vitamin H; prompt on vitamin B]

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Summary


2024 ACF Winter at UC Berkeley	2024-11-16	Y	3	23.33	100%	67%	67%
2024 ACF Winter at Brandeis	2024-11-16	Y	10	15.00	80%	50%	20%
2024 ACF Winter at Clemson	2024-11-16	Y	7	14.29	100%	29%	14%
2024 ACF Winter at Northwestern	2024-11-16	Y	9	18.89	100%	67%	22%
2024 ACF Winter at Ohio State	2024-11-16	Y	7	11.43	86%	29%	0%
2024 ACF Winter at Online	2024-11-16	Y	8	15.00	100%	50%	0%
2024 ACF Winter at Online	2024-11-16	Y	1	20.00	100%	100%	0%
2024 ACF Winter at UBC	2024-11-16	Y	3	16.67	100%	0%	67%
2024 ACF Winter at Oxford	2024-11-16	Y	10	14.00	100%	40%	0%

Data


UW B	Alberta	10	0	10
UBC B	SFU	10	10	20
UBC A	UW A	10	10	20