proteins - 2024 ACF Winter

Question

Structural information about these molecules is stored in the legacy .pdb file format, which can be used in molecular docking simulations of their interactions. For 10 points each:

[10m] Name these molecules that are designated as “bait” and “prey” in the two-hybrid assay to identify interactions between them. These molecules are often fragmented when sequenced via tandem mass spectrometry.

ANSWER: proteins [accept Protein Data Bank; accept protein–protein interactions; prompt on polypeptides]

[10e] Protein–protein interactions are in part driven by these dipole–dipole interactions between electronegative atoms and the lightest element.

ANSWER: hydrogen bonds [or hydrogen bonding or H-bonds or H-bonding]

[10h] A protein’s interactome can be found by fusing it with the promiscuous ligase BirA, which attaches this molecule to binding partners. Those partners are then purified for mass spec sequencing using this molecule’s high affinity for streptavidin.

ANSWER: biotin [or vitamin B7 or vitamin H; prompt on vitamin B]

Back to bonuses

Summary


2024 ACF Winter at UC Berkeley	2024-11-16	Y	3	23.33	100%	67%	67%
2024 ACF Winter at Clemson	2024-11-16	Y	8	12.50	88%	25%	13%
2024 ACF Winter at Northwestern	2024-11-16	Y	9	18.89	100%	67%	22%
2024 ACF Winter at Ohio State	2024-11-16	Y	7	11.43	86%	29%	0%
2024 ACF Winter at Online	2024-11-16	Y	8	15.00	100%	50%	0%
2024 ACF Winter at UBC	2024-11-16	Y	3	16.67	100%	0%	67%
2024 ACF Winter at Oxford	2024-11-16	Y	11	12.73	91%	36%	0%
2024 ACF Winter at Brandeis	2024-11-16	Y	10	15.00	80%	50%	20%

Data


Berkeley B	Berkeley A	10	10	10	30
Stanford A	Stanford L	0	10	0	10
Berkeley C	Stanford M	10	10	10	30
Georgia A	Alabama A	10	10	10	30
Auburn A	Georgia Tech D	0	10	0	10
Clemson A	Tennesse B	0	10	0	10
Emory A	Auburn C	0	10	0	10
Georgia Tech B	Georgia Tech E	0	10	0	10
Georgia Tech F	Auburn B	0	10	0	10
Emory B	South Carolina A	0	0	0	0
Georgia Tech C	Tusculum A	10	10	0	20
UIUC B	Indiana B	0	10	0	10
Purdue B	Miami	10	10	0	20
UIUC C	Northwestern A	0	10	0	10
Indiana A	Notre Dame	10	10	0	20
WashU B	Purdue A	0	10	0	10
UChicago A	Purdue C	10	10	10	30
WashU D	Purdue D	10	10	0	20
UChicago B	SIUE A	10	10	10	30
WashU C	UIUC D	10	10	0	20
CWRU A (UG)	CWRU C (UG)	0	10	0	10
OSU C	Kenyon A	0	10	0	10
Michigan A	Michigan State A	10	10	0	20
Michigan B	CWRU D (DII)	0	10	0	10
Michigan State C (UG)	Michigan C (UG)	0	0	0	0
Michigan D (DII)	CWRU B (UG)	0	10	0	10
Ohio State A (UG)	Pitt A	10	10	0	20
Texas B	Arkansas	10	10	0	20
Central Oklahoma	Vassar A	10	10	0	20
Texas A	Colorado College	0	10	0	10
Iowa	Texas D	0	10	0	10
McGill E	NYU B	10	10	0	20
Missouri	Mississippi State	0	10	0	10
Oregon State	Ole Miss	0	10	0	10
NYU A	Texas C	10	10	0	20
UW B	Alberta	0	10	0	10
UBC B	SFU	0	10	10	20
UBC A	UW A	0	10	10	20
Imperial A	Cambridge A	10	10	0	20
Cambridge B	Bristol A	10	10	0	20
LSE A	Cambridge C	0	10	0	10
Durham A	Cam D	0	0	0	0
Edinburgh	Bristol B	0	10	0	10
Oxford B	Imperial B	0	10	0	10
Oxford A	Manchester	10	10	0	20
Birmingham	Southampton A	0	10	0	10
Vanderbilt	LSE B	0	10	0	10
Southampton B	Warwick A	10	10	0	20
Durham B	Warwick B	0	10	0	10
A Brandeis Supreme	Clark A	0	10	0	10
Amherst A	Boston University A	10	10	10	30
Diamond Brandeis	Bowdoin B	0	0	0	0
Yale C	Brandeises Brew	10	10	10	30
MIT A	Brown A	10	10	0	20
Yale A	Carabrandeis	10	10	0	20
Harvard A	Northeastern A	10	10	0	20
Tufts B	Tufts A	0	0	0	0
Williams A	Bowdoin A	0	10	0	10
Yale B	Boston University B	0	10	0	10