Question
The expression of aquaporins in astrocytes has been hypothesized to contribute to this system. For 10 points each:
[10h] Name this system that removes waste from the central nervous system during sleep.
ANSWER: glymphatic system [reject “lymphatic system”]
[10m] Sleep deprivation has been linked to dementia in part due to decreased removal of this peptide by the glymphatic system when people are awake. Mutations in the APP gene can cause buildup of this peptide.
ANSWER: amyloid-beta [accept beta-amyloid plaques; prompt on amyloid or amyloid precursor protein]
[10e] The accumulation of beta amyloid plaques and neurofibrillary tangles formed by tau protein are possible leading contributors to this neurodegenerative disease, which is the most common cause of dementia.
ANSWER: Alzheimer’s disease [or AD]
<Biology>
Summary
| 2024 ACF Regionals @ Berkeley | 01/27/2024 | Y | 3 | 13.33 | 100% | 33% | 0% |
| 2024 ACF Regionals @ Cornell | 01/27/2024 | Y | 3 | 13.33 | 100% | 33% | 0% |
| 2024 ACF Regionals @ JMU | 01/27/2024 | Y | 10 | 12.00 | 100% | 20% | 0% |
| 2024 ACF Regionals @ Nebraska | 01/27/2024 | Y | 6 | 15.00 | 100% | 33% | 17% |
| 2024 ACF Regionals @ Ohio State | 01/27/2024 | Y | 3 | 16.67 | 100% | 67% | 0% |
| 2024 ACF Regionals @ Rutgers | 01/27/2024 | Y | 5 | 18.00 | 100% | 40% | 40% |
| 2024 ACF Regionals @ Imperial | 01/27/2024 | Y | 8 | 11.25 | 100% | 13% | 0% |
| 2024 ACF Regionals @ Vanderbilt | 01/27/2024 | Y | 5 | 12.00 | 100% | 0% | 20% |
Data
| Cambridge A | Cambridge B | 0 | 10 | 10 | 20 |
| Cambridge C | Oxford C | 0 | 0 | 10 | 10 |
| Durham A | Imperial B | 0 | 0 | 10 | 10 |
| Edinburgh | Imperial A | 0 | 0 | 10 | 10 |
| Sheffield | KCL | 0 | 0 | 10 | 10 |
| Kiel | Bristol | 0 | 0 | 10 | 10 |
| Durham B | Oxford B | 0 | 0 | 10 | 10 |
| Oxford A | Warwick | 0 | 0 | 10 | 10 |