glymphatic system - 2024 ACF Regionals

Question

The expression of aquaporins in astrocytes has been hypothesized to contribute to this system. For 10 points each:

[10h] Name this system that removes waste from the central nervous system during sleep.

ANSWER: glymphatic system [reject “lymphatic system”]

[10m] Sleep deprivation has been linked to dementia in part due to decreased removal of this peptide by the glymphatic system when people are awake. Mutations in the APP gene can cause buildup of this peptide.

ANSWER: amyloid-beta [accept beta-amyloid plaques; prompt on amyloid or amyloid precursor protein]

[10e] The accumulation of beta amyloid plaques and neurofibrillary tangles formed by tau protein are possible leading contributors to this neurodegenerative disease, which is the most common cause of dementia.

ANSWER: Alzheimer’s disease [or AD]

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Summary


2024 ACF Regionals @ Berkeley	01/27/2024	Y	3	13.33	100%	33%	0%
2024 ACF Regionals @ Cornell	01/27/2024	Y	3	13.33	100%	33%	0%
2024 ACF Regionals @ JMU	01/27/2024	Y	10	12.00	100%	20%	0%
2024 ACF Regionals @ Nebraska	01/27/2024	Y	6	15.00	100%	33%	17%
2024 ACF Regionals @ Ohio State	01/27/2024	Y	3	16.67	100%	67%	0%
2024 ACF Regionals @ Rutgers	01/27/2024	Y	5	18.00	100%	40%	40%
2024 ACF Regionals @ Imperial	01/27/2024	Y	8	11.25	100%	13%	0%
2024 ACF Regionals @ Vanderbilt	01/27/2024	Y	5	12.00	100%	0%	20%

Data


Cornell A	Cornell B	0	0	10	10
Cornell C	RIT A	0	0	10	10
Binghamton	RIT B	0	10	10	20
Liberty C (DII)	Liberty A (Grad)	0	0	10	10
Maryland A (Grad)	JMU B (UG)	0	10	10	20
Cambridge A	Cambridge B	0	10	10	20
Cambridge C	Oxford C	0	0	10	10
Durham A	Imperial B	0	0	10	10
Edinburgh	Imperial A	0	0	10	10
Sheffield	KCL	0	0	10	10
UNC A (Grad)	Maryland B (UG)	0	0	10	10
GWU A (UG)	Maryland C (DII)	0	0	10	10
Roanoke College A (DII)	JMU A (UG)	0	0	10	10
UNC B (UG)	Duke A (UG)	0	10	10	20
UNC C (UG)	Liberty B (DII)	0	0	10	10
Virginia B (UG)	UNC D (DII)	0	0	10	10
Virginia A (UG)	GWU B (Grad)	0	0	10	10
Virginia C (UG)	William & Mary A (UG)	0	0	10	10
Claremont A	UBC A	0	10	10	20
Iowa A	Rice A	0	0	10	10
Michigan State A	Appalachian State	0	0	10	10
Texas A&M A	Iowa B	10	10	10	30
UW A	Texas A&M B	0	0	10	10
Sorbonne	Texas A	0	0	10	10
Cedarville	Kenyon	0	0	10	10
Ohio State A	Michigan A	0	10	10	20
Michigan C	Michigan B	0	10	10	20
Kiel	Bristol	0	0	10	10
Durham B	Oxford B	0	0	10	10
Oxford A	Warwick	0	0	10	10
Vanderbilt A	Alabama	0	0	10	10
Georgia Tech B	Georgia Tech A	0	0	10	10
Geodesic	Kentucky	10	0	10	20
South Carolina	Harding	0	0	10	10
MTSU	Vanderbilt B	0	0	10	10
Berkeley A	Berkeley C	0	0	10	10
Stanford B	Stanford A	0	0	10	10
Berkeley B	Stanford C	0	10	10	20
Johns Hopkins	Columbia C	0	0	10	10
NYU A	Haverford	0	0	10	10
John Jay	Vassar	0	0	10	10
Penn	NYU B	10	10	10	30
Columbia A	Rowan	10	10	10	30