Parkinson’s disease - 2025 ACF Regionals

Question

In a namesake hypothesis, Heiko Braak described how this disease begins in the brain’s olfactory nucleus. For 10 points each:

[10e] Name this neurodegenerative condition characterized by a shuffling gait, rigidity, and tremors.

ANSWER: Parkinson’s disease [or PD]

[10h] Braak suggested that one cause of Parkinson’s is the aggregation of this protein within Lewy bodies, inhibiting the release of dopamine. High accumulation of this protein may also cause multiple system atrophy.

ANSWER: alpha-synuclein [or SCNA; prompt on synuclein]

[10m] Parkinson’s can be detected using a type of MRI imaging named for this substance. Dopaminergic neuron loss during Parkinson’s occurs in an area of the brain containing a high level of this substance called the substantia nigra.

ANSWER: melanin [accept neuromelanin]

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Summary


California	2025-02-01	Y	3	13.33	100%	0%	33%
Great Lakes	2025-02-01	Y	5	10.00	80%	20%	0%
Lower Mid-Atlantic	2025-02-01	Y	6	10.00	100%	0%	0%
Midwest	2025-02-01	Y	6	15.00	100%	17%	33%
North	2025-02-01	Y	3	13.33	100%	33%	0%
Overflow	2025-02-01	Y	5	12.00	100%	0%	20%
Pacific Northwest	2025-02-01	Y	2	10.00	100%	0%	0%
South Central	2025-02-01	Y	2	15.00	100%	0%	50%
Southeast	2025-02-01	Y	4	17.50	100%	25%	50%
UK	2025-02-01	Y	11	15.45	91%	46%	18%
Upper Mid-Atlantic	2025-02-01	Y	8	12.50	75%	25%	25%
Upstate NY	2025-02-01	Y	2	10.00	100%	0%	0%

Data


UCLA	Claremont A	10	0	0	10
Ohio State A	Carnegie Mellon A	10	0	10	20
Michigan D	Carnegie Mellon B	10	0	0	10
UNC C	Liberty B	10	0	0	10
Virginia A	Wake Forest	10	0	0	10
Indiana A	Illinois A	10	0	0	10
Missouri	Chicago C	10	10	0	20
Georgetown A	Stanford B	10	0	0	10
UW A	Alberta	10	0	0	10
Georgia Tech C	Alabama A	10	0	10	20
Vanderbilt A	Louisville A	10	10	0	20
Tennessee A	Georgia Tech D	10	0	0	10
Cambridge B	Cambridge D	10	0	10	20
Cambridge B	Cambridge D	10	0	10	20
Cambridge B	Cambridge D	10	0	0	10
Cambridge B	Cambridge D	10	0	0	10
Cambridge B	Cambridge D	10	0	10	20
Cambridge B	Cambridge D	10	0	10	20
Cambridge B	Cambridge D	10	0	0	10
Cambridge B	Cambridge D	10	0	0	10
Durham	Imperial A	10	0	0	10
Case Western A	Case Western B	10	0	0	10
Michigan A	Michigan State	0	0	0	0
Kenyon	Ohio State B	10	0	0	10
William & Mary	Duke	10	0	0	10
Liberty A	UNC B	10	0	0	10
Liberty C	UNC D	10	0	0	10
Virginia Tech A	South Carolina	10	0	0	10
Northwestern A	Georgetown B	10	10	0	20
Iowa	Notre Dame B	10	0	0	10
Northwestern B	Purdue	10	0	0	10
Notre Dame A	Notre Dame C	10	0	0	10
UBC	UW B	10	0	0	10
Texas A	TAMU	10	0	0	10
ASU	Texas B	10	10	0	20
Bruin A	Georgia Tech B	10	10	0	20
Sheffield	Bristol	10	0	0	10
NYU C	Southampton B	10	0	0	10
Columbia B	Haverford B	10	0	10	20
Cornell B	Columbia C	10	10	10	30
John Jay College	NYU A	10	0	0	10
Rutgers A	Johns Hopkins A	0	10	0	10
Maryland B	Penn B	10	0	0	10
NYU B	George Washington A	10	0	0	10
George Washington B	Penn A	10	0	0	10
Yale A	Vassar A	0	0	0	0
UC Berkeley A	Claremont B	10	0	0	10
UC Berkeley B	UCSD	10	10	0	20
Chicago A	Chicago B	10	10	10	30
Missouri S&T	Chicago D	10	0	0	10
Illinois B	Indiana B	10	0	0	10
Illinois C	WashU A	10	0	0	10
Carleton	Wisconsin A	10	0	0	10
Winona State	Iowa State	10	0	0	10
Minnesota B	Wisconsin B	10	0	10	20
Cambridge A	Oxford B	10	10	10	30
Cambridge C	Cambridge E	10	0	10	20
Imperial B	LSE	0	0	10	10
Warwick A	Manchester	10	0	0	10
Oxford A	Warwick B	10	10	10	30
Oxford C	Southampton A	10	0	0	10
ESF A	Cornell D	10	0	0	10
RIT A	Cornell C	10	0	0	10