GWAS - 2025 ACF Regionals - Buzzpoints App

Question

After performing this type of study, the Sum of Single Effects model, or SuSie, is used to generate probabilistic “credible sets” in a process called fine-mapping. For 10 points each:

[10h] Name this type of study often performed using the PLINK package. Data from these studies are used to calculate polygenic risk scores.

ANSWER: GWAS (“G-woss”) [or genome-wide-association studies or GWA studies]

[10m] Fine-mapping can be used to determine causal variants from microarrays containing many of these things. Each dot on a Manhattan plot corresponds to one of these things, which are point mutations that occur in at least 1 percent of the population.

ANSWER: SNPs (“snips”) [or single nucleotide polymorphisms]

[10e] Tools like PLINK contain methods for pruning this phenomenon’s namesake “disequilibrium” to eliminate non-unique SNPs. In this phenomenon, two genes that are close together on a chromosome are inherited together.

ANSWER: genetic linkage

Back to bonuses

Summary


California	2025-02-01	Y	3	20.00	100%	67%	33%
Great Lakes	2025-02-01	Y	6	8.33	50%	33%	0%
Lower Mid-Atlantic	2025-02-01	Y	6	13.33	83%	50%	0%
Midwest	2025-02-01	Y	6	26.67	83%	100%	83%
Overflow	2025-02-01	Y	5	18.00	60%	60%	60%
Pacific Northwest	2025-02-01	Y	2	10.00	50%	50%	0%
Southeast	2025-02-01	Y	3	10.00	33%	33%	33%
UK	2025-02-01	Y	10	10.00	40%	40%	20%
California	2025-02-01	N	3	13.33	100%	0%	33%
Great Lakes	2025-02-01	N	5	10.00	80%	20%	0%
Lower Mid-Atlantic	2025-02-01	N	6	10.00	100%	0%	0%
Midwest	2025-02-01	N	6	15.00	100%	17%	33%
North	2025-02-01	N	3	13.33	100%	33%	0%
Overflow	2025-02-01	N	5	12.00	100%	0%	20%
Pacific Northwest	2025-02-01	N	2	10.00	100%	0%	0%
South Central	2025-02-01	N	2	15.00	100%	0%	50%
Southeast	2025-02-01	N	4	17.50	100%	25%	50%
UK	2025-02-01	N	5	16.00	100%	40%	20%
Upper Mid-Atlantic	2025-02-01	N	8	12.50	75%	25%	25%
Upstate NY	2025-02-01	N	2	10.00	100%	0%	0%
2025 Chicago Open	2025-08-09	N	10	10.00	60%	40%	0%

Data


Claremont A	Claremont B	10	10	10	30
UC Berkeley A	UC Berkeley B	0	10	10	20
UCLA	UCSD	0	0	10	10
Michigan State	Carnegie Mellon B	0	0	0	0
Case Western B	Michigan D	0	0	0	0
Case Western A	Kenyon	0	0	10	10
Michigan A	Ohio State A	0	10	10	20
Carnegie Mellon A	Michigan B	0	10	10	20
Ohio State B	Michigan C	0	0	0	0
Virginia A	Liberty A	0	0	10	10
Liberty B	Liberty C	0	0	0	0
Virginia Tech A	William & Mary	0	10	10	20
Indiana A	Chicago D	10	10	10	30
WashU A	Illinois B	10	10	10	30
WashU B	Illinois C	10	10	10	30
Illinois A	Indiana B	10	10	10	30
Chicago C	Missoui S&T	0	10	0	10
Chicago B	Missouri	10	10	10	30
Georgetown A	Northwestern B	0	0	0	0
Georgetown B	Notre Dame C	0	0	0	0
Stanford B	Iowa	10	10	10	30
Northwestern A	Notre Dame A	10	10	10	30
Purdue	Notre Dame B	10	10	10	30
Alberta	UBC	0	10	0	10
UW B	UW A	0	0	10	10
Georgia Tech C	Bruin A	10	10	10	30
Louisville A	Georgia Tech A	0	0	0	0
Cambridge C	Cambridge B	10	10	10	30
Southampton B	Cambridge D	0	0	0	0
Cambridge E	Oxford C	0	10	10	20
Imperial A	LSE	10	10	10	30
NYU C	Southampton A	0	0	0	0
Oxford A	Cambridge A	0	10	10	20
Imperial B	Oxford B	0	0	0	0
Sheffield	Manchester	0	0	0	0
Bristol	Warwick A	0	0	0	0
Durham	Warwick B	0	0	0	0
Vanderbilt A	Alabama A	0	0	0	0
Duke	South Carolina	0	10	10	20
UNC C	UNC D	0	0	10	10
UNC B	Wake Forest	0	10	10	20