Question
After performing this type of study, the Sum of Single Effects model, or SuSie, is used to generate probabilistic “credible sets” in a process called fine-mapping. For 10 points each:
[10h] Name this type of study often performed using the PLINK package. Data from these studies are used to calculate polygenic risk scores.
ANSWER: GWAS (“G-woss”) [or genome-wide-association studies or GWA studies]
[10m] Fine-mapping can be used to determine causal variants from microarrays containing many of these things. Each dot on a Manhattan plot corresponds to one of these things, which are point mutations that occur in at least 1 percent of the population.
ANSWER: SNPs (“snips”) [or single nucleotide polymorphisms]
[10e] Tools like PLINK contain methods for pruning this phenomenon’s namesake “disequilibrium” to eliminate non-unique SNPs. In this phenomenon, two genes that are close together on a chromosome are inherited together.
ANSWER: genetic linkage
<Chicago A, Biology>
Summary
| California | 2025-02-01 | Y | 3 | 20.00 | 100% | 67% | 33% |
| Great Lakes | 2025-02-01 | Y | 6 | 8.33 | 50% | 33% | 0% |
| Lower Mid-Atlantic | 2025-02-01 | Y | 6 | 13.33 | 83% | 50% | 0% |
| Midwest | 2025-02-01 | Y | 6 | 26.67 | 83% | 100% | 83% |
| Overflow | 2025-02-01 | Y | 5 | 18.00 | 60% | 60% | 60% |
| Pacific Northwest | 2025-02-01 | Y | 2 | 10.00 | 50% | 50% | 0% |
| Southeast | 2025-02-01 | Y | 3 | 10.00 | 33% | 33% | 33% |
| UK | 2025-02-01 | Y | 10 | 10.00 | 40% | 40% | 20% |
Data
| Claremont A | Claremont B | 10 | 10 | 10 | 30 |
| UC Berkeley A | UC Berkeley B | 0 | 10 | 10 | 20 |
| UCLA | UCSD | 0 | 0 | 10 | 10 |