This disease was shown to have increased correlation with celiac disease by studies following Dorothy Hansine Andersen’s research on how it affects the pancreas. This disease is treated by modulators like ivacaftor and lumacaftor. The A·B·C·C·7 gene codes for an ABC-class transporter for ions like thiocyanate whose malfunction is a hallmark of this disease. This disease is caused by a mutation in the first nucleotide-binding domain of a (*) transmembrane conductance regulator, in which phenyl·alanine 508 is deleted. It’s not sickle cell anemia, but heterozygous advantage from the mutation that causes this disease confers resistance against cholera. Abnormal salt levels in a sweat test are used to diagnose this autosomal recessive disease. For 10 points, what genetic disease leads to a buildup of mucus? ■END■
| 2025 PLAYTIME Online | 04/26/2025 | Y | 9 | 100% | 44% | 0% | 65.78 |
| 2024 PLAYTIME @ Harvard | 04/26/2025 | Y | 4 | 100% | 0% | 0% | 93.00 |
| 2024 PLAYTIME @ Virginia Tech | 07/11/2025 | Y | 3 | 100% | 0% | 67% | 107.33 |
| 2024 PLAYTIME @ UBC | 10/05/2024 | Y | 7 | 86% | 0% | 14% | 88.50 |
| 2024 PLAYTIME @ WashU | 10/12/2024 | Y | 6 | 100% | 0% | 17% | 86.67 |
| 2024 PLAYTIME @ JHU | 10/26/2024 | Y | 7 | 100% | 0% | 14% | 104.29 |
| 2025 PLAYTIME @ Northwest | 12/10/2024 | Y | 4 | 75% | 25% | 25% | 76.67 |
| 2025 PLAYTIME @ Claremont | 12/10/2024 | Y | 5 | 100% | 0% | 0% | 93.20 |
| 2025 PLAYTIME @ Florida | 12/10/2024 | Y | 3 | 100% | 0% | 0% | 70.33 |
| 2025 PLAYTIME @ CWRU | 12/10/2024 | Y | 5 | 100% | 0% | 0% | 78.60 |
| 2025 PLAYTIME @ Sheffield | 12/10/2024 | Y | 7 | 100% | 29% | 43% | 89.71 |
| Player | Team | Opponent | Buzz Position | Value |
|---|---|---|---|---|
| CT Tang | Sheffield C | Sheffield B | 16 | -5 |
| Eric Mukherjee | Mike Dukakis Tank Battalion | Free Agents 1 | 31 | 15 |
| Bryan Ugaz | Arizona State University A | UW B | 33 | 15 |
| Eloise Wood | Imperial B | Lancaster | 33 | 15 |
| Nathan Easow | Manchester | Warwick A | 35 | -5 |
| Micah Colman | Waterloo B | Simon Fraser | 40 | -5 |
| Theenash Sengupta | MSJ | Quatumvirate | 43 | 15 |
| Ameya Bhalerao | mongeese | Notre Dame + Epic Games | 50 | 15 |
| Nathan Liang | Mahjonng Masters | Illinois Orange | 53 | 15 |
| Brendan Bethlehem | Cambridge | Birmingham | 63 | 15 |
| Sky Hong | we need new names | Auburn 2026 | 68 | 10 |
| Khanh Nguyen | Project2025BC: Make Assyria Great Again | Too much from you lately | 69 | 10 |
| Calvin Bostleman | Ohio State A | Ohio State C | 69 | 10 |
| Chloe Chow | Harvard | RIT | 69 | 10 |
| Tracy Mirkin | Edwin Laundrorat's Long-Lost Man Unclothès Rat Degrosses | Qin Shi Huang's Immortality Poison | 70 | 10 |
| Yashwanth Bajji | Michigan A | Oberlin | 70 | 10 |
| Billy Beyer | Billy's Bastion | Keeping Up With the Cardassians | 72 | 10 |
| Daniel Sheinberg | Trip-Hop Quizzer Tricky | evil women enjoyers | 72 | 10 |
| June Yin | WashU Squirtle | Illinois B | 72 | 10 |
| Ava Butler | McGill A | Waterloo C | 72 | 10 |
| Biyang Zhang | Michigan B | Michigan C | 73 | 10 |
| Halee Carey | Mac A | Toronto Metropolitan | 73 | 10 |
| Euan McCubbin | UW A | Alberta | 74 | 10 |
| Raymond Chen | Toronto C | Toronto B | 74 | 10 |
| Aditya Patnaik | Ohio State D | Michigan D | 75 | 10 |
| Shahar Schwartz | Egypt Airlines Haters | Monsieur Hulot's Academic Team | 76 | 10 |
| Stan | Gruh | Four Generalists in Search of a Power | 76 | 10 |
| Jason Cheng | P.C.‚ Daniel‚ Michel‚ and Jason B | UCLA B | 76 | 10 |
| Payton Chung | girl 15 whale i mean they | UCSD | 76 | 10 |
| Logan Mathis | SIUE | Chicago B | 76 | 10 |
| Arthur Gayden | Chicago A | Truman State | 76 | 10 |
| Jacob Egol | Master and Margaritaville | 4 quizbowl pros go Virginia on North Carolina | 76 | 10 |
| Braden Booth | Missouri | Iowa State | 76 | -5 |
| Neal Joshi | WashU Bulbasaur | Illinois A | 78 | 10 |
| Liam Kusalik | Waterloo A | Toronto A | 80 | 10 |
| Anderson Wang | Art of Premature Signaling | UCSB | 81 | 10 |
| Jonathan Shauf | Even in Blacksburg There I Am | Ashurbanipal’s Drag Race | 81 | -5 |
| Andy Huff | LSE | Sheffield | 83 | 10 |
| Alan Lee | CWRU | Rutgers | 84 | 10 |
| Gregory Zeldovich | Belmont | BU | 95 | 10 |
| Andy Yu | Maryland A | Catholic University of America | 95 | 10 |
| John John Groger | WashU Charmander | Illinois C | 95 | 10 |
| Elizabeth Jewlal | Johns Hopkins A | George Mason C | 96 | 10 |
| Padraig Finan | Washington Connections | Carleton | 96 | -5 |
| Adsayan Ganesh | Warwick B | Warwick C | 96 | 10 |
| Yrwin Batan | MIT | Lexington | 98 | 10 |
| Cole Hartung | Georgetown | Haverford B | 102 | 10 |
| Jacob Goodson | Ohio State B | Pittsburgh | 106 | 10 |
| Ryan Rosenberg | Adrianne Lenker 4 Nobel Lit Prize 2K65 | Somehow Paula Deen Returned | 106 | -5 |
| Ben Spirtas | Maryland B | George Mason A | 108 | -5 |
| Jacob Hardin-Bernhardt | NYU A | NYU C | 108 | 10 |
| Laura Bullock | Sheffield B | Sheffield C | 108 | 10 |
| Denali Tran-Le | McGill B | Toronto D | 109 | 10 |
| Annika Larson | Claremont B | UCLA A | 110 | 10 |
| Kayla Drajpuch | Brandeis | Brown | 110 | 10 |
| Ted Harrison | Edinburgh | Imperial A | 111 | -5 |
| Lesley Kwarteng | Johns Hopkins B | George Washington | 122 | 10 |
| Chris Levesley | Warwick A | Manchester | 122 | 10 |
| Alex Xu | Caltech | Claremont A | 123 | 10 |
| Nicholas Decker | George Mason A | Maryland B | 123 | 10 |
| Taman Truong | Arizona State University B | South Dakota School of Mines | 123 | 10 |
| Coy Mier | Goober Gang | 2 Italians, 2 Poles, All Noles | 123 | 10 |
| Eugenia Tong | Imperial A | Edinburgh | 123 | 10 |
| Elijah Mandelbaum | Guelph | UBC | 123 | 0 |
| Tai Belke | UBC | Guelph | 123 | 0 |
| Kevin Ye | Simon Fraser | Waterloo B | 123 | 10 |
| Vasa Clarke | Somehow Paula Deen Returned | Adrianne Lenker 4 Nobel Lit Prize 2K65 | 123 | 10 |
| Matt Weiner | Ashurbanipal’s Drag Race | Even in Blacksburg There I Am | 123 | 10 |
| Conor Thompson | Iowa State | Missouri | 123 | 10 |