hallucinogenicity - 2023 Penn Bowl

Question

Description acceptable. psychLight offers a cell-based platform to detect this property in cells through specific conformations of the 5-HT2A receptor. For 10 points each:

[10m] The mouse head twitch response is an in vivo assay for this property of compounds that is often exhibited by tryptamines.

ANSWER: hallucinogenicity [accept descriptive equivalents]

[10e] The hallucinogens psilocybin and 5-MeO-DMT are currently in clinical trials for this psychiatric condition’s treatment-resistant form, where patients do not respond to traditional medications such as SSRIs.

ANSWER: depression

[10h] The psychLight experiments used this fluorescent reporter derived from the red coral Discosoma to label dendrites. This fluorescent protein is very bright because of its tandem dimer structure that functions at low levels.

ANSWER: tdTomato [prompt on DsRed; prompt on red fluorescent protein or RFP]

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Summary


2023 Penn Bowl (Harvard)	10/21/2023	Y	3	10.00	100%	0%	0%
2023 Penn Bowl (Mainsite)	10/21/2023	Y	6	10.00	100%	0%	0%
2023 Penn Bowl @ Waterloo	10/28/2023	N	3	10.00	100%	0%	0%
2023 Penn Bowl @ FSU	10/28/2023	N	2	15.00	100%	50%	0%
2023 Penn Bowl (Norcal)	10/28/2023	N	2	15.00	100%	0%	50%
2023 Penn Bowl (South Central)	10/28/2023	N	3	16.67	100%	0%	67%
2023 Penn Bowl (UK)	10/28/2023	N	5	10.00	80%	0%	20%
2023 Penn Bowl @ UNC	10/28/2023	N	4	15.00	100%	0%	50%

Data


MIT	Boston College	10	10
Brown	Tufts	10	10
JHU B	Columbia B	10	10
JHU A	John Jay	10	10
Columbia A	NYU	10	10
UMD A	RIT	10	10
Cornell B	Swarthmore	10	10
RIT	UMD B	10	10
Harvard	Brandeis	10	10