Question
Description acceptable. psychLight offers a cell-based platform to detect this property in cells through specific conformations of the 5-HT2A receptor. For 10 points each:
[10m] The mouse head twitch response is an in vivo assay for this property of compounds that is often exhibited by tryptamines.
ANSWER: hallucinogenicity [accept descriptive equivalents]
[10e] The hallucinogens psilocybin and 5-MeO-DMT are currently in clinical trials for this psychiatric condition’s treatment-resistant form, where patients do not respond to traditional medications such as SSRIs.
ANSWER: depression
[10h] The psychLight experiments used this fluorescent reporter derived from the red coral Discosoma to label dendrites. This fluorescent protein is very bright because of its tandem dimer structure that functions at low levels.
ANSWER: tdTomato [prompt on DsRed; prompt on red fluorescent protein or RFP]
<Vishal Kanigicherla, Biology>
Summary
| 2023 Penn Bowl (Harvard) | 10/21/2023 | Y | 3 | 10.00 | 100% | 0% | 0% |
| 2023 Penn Bowl (Mainsite) | 10/21/2023 | Y | 6 | 10.00 | 100% | 0% | 0% |