Question
Liberty Blue and Liberty Prime are two instruments produced by CEM that enable the synthesis of molecules in this fashion, starting with reagents named Wang or Rank Amide. For 10 points each:
[10h] Name this form of synthesis that underpins “split and pool” synthesis. Peptides synthesized in this manner are immediately treated afterwards with a cocktail of 95-percent TFA supplemented with TIS and DODT.
ANSWER: solid-phase synthesis [accept on-resin synthesis; accept solid-phase peptide synthesis or on-resin peptide synthesis]
[10m] The aforementioned cocktail is used to remove the final products from the resin and to remove these modifications. The compounds Fmoc (“F-mock”) and Boc (“bock”) are used as these modifications.
ANSWER: protecting groups [or protective groups]
[10e] Each round of solid-phase peptide synthesis begins with the removal of Fmoc by adding one of these compounds while leaving Boc and Trt untouched. These compounds form solutions with a high pH.
ANSWER: bases
<Arizona State, Chemistry>
Summary
| Florida | 2025-02-01 | Y | 3 | 13.33 | 67% | 67% | 0% |
| Great Lakes | 2025-02-01 | Y | 5 | 14.00 | 100% | 40% | 0% |
| Lower Mid-Atlantic | 2025-02-01 | Y | 6 | 13.33 | 83% | 33% | 17% |
| Midwest | 2025-02-01 | Y | 2 | 20.00 | 100% | 100% | 0% |
| North | 2025-02-01 | Y | 3 | 13.33 | 100% | 33% | 0% |
| Northeast | 2025-02-01 | Y | 5 | 10.00 | 80% | 20% | 0% |
| Overflow | 2025-02-01 | Y | 5 | 16.00 | 100% | 40% | 20% |
| Pacific Northwest | 2025-02-01 | Y | 2 | 10.00 | 50% | 50% | 0% |
| Southeast | 2025-02-01 | Y | 3 | 13.33 | 100% | 33% | 0% |
| UK | 2025-02-01 | Y | 9 | 13.33 | 89% | 33% | 11% |
| Upper Mid-Atlantic | 2025-02-01 | Y | 8 | 13.75 | 88% | 38% | 13% |
| Upstate NY | 2025-02-01 | Y | 2 | 10.00 | 100% | 0% | 0% |
Data
| Notre Dame A | Georgetown A | 0 | 0 | 10 | 10 |
| Stanford B | Georgetown B | 0 | 10 | 10 | 20 |
| Northwestern A | Notre Dame B | 10 | 10 | 10 | 30 |
| Northwestern B | Notre Dame C | 0 | 0 | 10 | 10 |
| Iowa | Purdue | 0 | 0 | 10 | 10 |