solid-phase synthesis - 2025 ACF Regionals

Question

Liberty Blue and Liberty Prime are two instruments produced by CEM that enable the synthesis of molecules in this fashion, starting with reagents named Wang or Rank Amide. For 10 points each:

[10h] Name this form of synthesis that underpins “split and pool” synthesis. Peptides synthesized in this manner are immediately treated afterwards with a cocktail of 95-percent TFA supplemented with TIS and DODT.

ANSWER: solid-phase synthesis [accept on-resin synthesis; accept solid-phase peptide synthesis or on-resin peptide synthesis]

[10m] The aforementioned cocktail is used to remove the final products from the resin and to remove these modifications. The compounds Fmoc (“F-mock”) and Boc (“bock”) are used as these modifications.

ANSWER: protecting groups [or protective groups]

[10e] Each round of solid-phase peptide synthesis begins with the removal of Fmoc by adding one of these compounds while leaving Boc and Trt untouched. These compounds form solutions with a high pH.

ANSWER: bases

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Summary


Florida	2025-02-01	Y	3	13.33	67%	67%	0%
Great Lakes	2025-02-01	Y	5	14.00	100%	40%	0%
Lower Mid-Atlantic	2025-02-01	Y	6	13.33	83%	33%	17%
Midwest	2025-02-01	Y	2	20.00	100%	100%	0%
North	2025-02-01	Y	3	13.33	100%	33%	0%
Northeast	2025-02-01	Y	5	10.00	80%	20%	0%
Overflow	2025-02-01	Y	5	16.00	100%	40%	20%
Pacific Northwest	2025-02-01	Y	2	10.00	50%	50%	0%
Southeast	2025-02-01	Y	3	13.33	100%	33%	0%
UK	2025-02-01	Y	9	13.33	89%	33%	11%
Upper Mid-Atlantic	2025-02-01	Y	8	13.75	88%	38%	13%
Upstate NY	2025-02-01	Y	2	10.00	100%	0%	0%

Data


Florida A	Valencia A	0	10	10	20
Chicago A	Illinois A	0	10	10	20
Missouri	Chicago B	0	10	10	20
Iowa State	Minnesota B	0	10	10	20
Brandeis B	Brown A	0	0	10	10
MIT A	Dartmouth A	0	0	10	10
Georgia Tech C	Georgia Tech B	0	10	10	20
Cambridge B	Southampton A	0	10	10	20
Cambridge C	Southampton B	0	0	10	10
Cornell D	Cornell C	0	0	10	10
RIT A	RIT B	0	0	10	10
Case Western A	Carnegie Mellon A	0	10	10	20
Michigan D	Michigan B	0	0	10	10
Michigan A	Michigan C	0	10	10	20
Ohio State A	Michigan State	0	0	10	10
Ohio State B	Case Western B	0	0	10	10
Duke	Liberty B	0	0	10	10
South Carolina	Liberty C	0	0	10	10
Virginia Tech A	UNC B	0	10	10	20
UNC C	Virginia A	10	10	10	30
UNC D	Liberty A	0	0	0	0
William & Mary	Wake Forest	0	0	10	10
Notre Dame A	Georgetown A	0	0	10	10
Stanford B	Georgetown B	0	10	10	20
Northwestern A	Notre Dame B	10	10	10	30
Northwestern B	Notre Dame C	0	0	10	10
Iowa	Purdue	0	0	10	10
UW A	Alberta	0	0	0	0
UW B	UBC	0	10	10	20
Columbia B	Penn B	0	0	10	10
Cornell B	NYU B	0	10	10	20
Johns Hopkins A	George Washington A	0	10	10	20
Rutgers A	Haverford A	0	0	10	10
George Washington B	John Jay College	0	0	0	0
Maryland A	Maryland B	0	0	10	10
NYU A	Haverford B	0	0	10	10
Columbia C	Yale A	10	10	10	30
Florida B	UCF C	0	10	10	20
UCF B	Florida State A	0	0	0	0
Winona State	Wisconsin A	0	0	10	10
Carleton	Wisconsin B	0	0	10	10
BU	Tufts A	0	0	10	10
Brandeis A	Harvard B	0	0	0	0
Harvard A	UMass Boston	0	10	10	20
Alabama A	Vanderbilt A	0	0	10	10
Bruin A	Louisville A	0	0	10	10
Oxford A	Bristol	0	10	10	20
Cambridge A	Manchester	0	0	10	10
Warwick B	Cambridge D	0	0	10	10
Warwick A	Cambridge E	0	0	10	10
Imperial B	Oxford C	10	10	10	30
Oxford B	Imperial A	0	0	0	0
Sheffield	LSE	0	0	10	10