RNA splicing - Northeast - Buzzpoints App

Question

A 2015 study by Singh et al. found that HIV-1 prefers integration into genes where transcription and this other downstream process are both highly active. For 10 points each:

[10m] Name this process that involves the assembly of U1 to U6 snRNPs (“snurps”) into its namesake complex. HIV-1 hijacks host machinery to perform this process using four donor and seven acceptor sites.

ANSWER: RNA splicing [or word forms; accept alternative splicing; accept minor or major spliceosome assembly]

[10e] Early, unspliced HIV-1 transcripts are transported out of this organelle after Rev proteins bind exportin and Ran-GTP. Splicing factors are concentrated in Cajal bodies found in this organelle, which stores genomic DNA.

ANSWER: cellular nucleus [or cellular nuclei]

[10h] HIV-1 also evades this pathway by sequestering UPF1, a core component of its SURF complex. mRNA splicing errors are corrected by this pathway, which is triggered by the retention of exon-exon junction complexes.

ANSWER: nonsense-mediated decay [or NMD; prompt on mRNA decay; prompt on mRNA surveillance; reject “non-stop decay”]

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Summary


California (North)	Main Site	Y	3	10.00	100%	0%	0%
California (South)	Main Site	Y	4	15.00	100%	50%	0%
Florida	Main Site	Y	3	10.00	100%	0%	0%
Great Lakes	Main Site	Y	4	10.00	75%	25%	0%
Lower Mid-Atlantic	Main Site	Y	9	12.22	89%	33%	0%
Midwest	Main Site	Y	9	12.22	100%	11%	11%
Northeast	Main Site	Y	6	16.67	100%	67%	0%
Overflow	Main Site	Y	4	10.00	100%	0%	0%
South Central	Main Site	Y	2	10.00	50%	50%	0%
Southeast	Main Site	Y	7	11.43	100%	14%	0%
UK	Main Site	Y	6	15.00	100%	33%	17%
Upper Mid-Atlantic	Main Site	Y	8	15.00	100%	38%	13%
Upstate NY	Main Site	Y	4	10.00	100%	0%	0%

Data


MIT	Bowdoin A	10	10	20
Harvard A	Bowdoin B	10	10	20
Brandeis B	Brandeis A	0	10	10
Brown	Southern Connecticut State	10	10	20
Harvard B	Dartmouth A	0	10	10
Yale	Dartmouth B	10	10	20