A 2015 study by Singh et al. found that HIV-1 prefers integration into genes where transcription and this other downstream process are both highly active. For 10 points each:
[10m] Name this process that involves the assembly of U1 to U6 snRNPs (“snurps”) into its namesake complex. HIV-1 hijacks host machinery to perform this process using four donor and seven acceptor sites.
ANSWER: RNA splicing [or word forms; accept alternative splicing; accept minor or major spliceosome assembly]
[10e] Early, unspliced HIV-1 transcripts are transported out of this organelle after Rev proteins bind exportin and Ran-GTP. Splicing factors are concentrated in Cajal bodies found in this organelle, which stores genomic DNA.
ANSWER: cellular nucleus [or cellular nuclei]
[10h] HIV-1 also evades this pathway by sequestering UPF1, a core component of its SURF complex. mRNA splicing errors are corrected by this pathway, which is triggered by the retention of exon-exon junction complexes.
ANSWER: nonsense-mediated decay [or NMD; prompt on mRNA decay; prompt on mRNA surveillance; reject “non-stop decay”]
<Oxford A, Biology>