One of these proteins can be formed from the dimerization of MafB with Fra-1 or Fra-2. For 10 points each:
[10m] Name these proteins that include Activator protein 1, or AP-1. In eukaryotes, a “general” one of these proteins possesses a TBP subunit that recognizes the TATA box.
ANSWER: transcription factors [or TFs; accept general transcription factors; accept TFIID]
[10h] Proteins that dimerize to form AP-1, such as c-Jun and c-Fos, contain basic domains named for this structural motif. Alpha helices that bind to each other to form this motif contain a namesake residue at every seventh position.
ANSWER: leucine zippers [accept basic-region leucine zipper domains; prompt on bZIP domains or bZIP transcription factors; prompt on coiled coils; reject “leucine-rich repeats” or “LRRs”]
[10e] AP-1 dysfunction has been shown to influence the formation of these abnormal solid cell masses, which can be called cancerous if malignant.
ANSWER: tumors [or neoplasms; accept tumorigenesis; prompt on carcinomas]
<Kane Nguyen, Biology>