transcription factors - 2025 Penn Bowl

Question

One of these proteins can be formed from the dimerization of MafB with Fra-1 or Fra-2. For 10 points each:

[10m] Name these proteins that include Activator protein 1, or AP-1. In eukaryotes, a “general” one of these proteins possesses a TBP subunit that recognizes the TATA box.

ANSWER: transcription factors [or TFs; accept general transcription factors; accept TFIID]

[10h] Proteins that dimerize to form AP-1, such as c-Jun and c-Fos, contain basic domains named for this structural motif. Alpha helices that bind to each other to form this motif contain a namesake residue at every seventh position.

ANSWER: leucine zippers [accept basic-region leucine zipper domains; prompt on bZIP domains or bZIP transcription factors; prompt on coiled coils; reject “leucine-rich repeats” or “LRRs”]

[10e] AP-1 dysfunction has been shown to influence the formation of these abnormal solid cell masses, which can be called cancerous if malignant.

ANSWER: tumors [or neoplasms; accept tumorigenesis; prompt on carcinomas]

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Summary


2025 Penn Bowl - BU	11/01/25	Y	4	20.00	100%	75%	25%
2025 Penn Bowl - CWRU	11/01/25	Y	3	20.00	100%	67%	33%
2025 Penn Bowl - Mainsite (UPenn)	11/01/25	Y	6	18.33	100%	33%	50%
2025 Penn Bowl - Murray State	11/08/25	Y	2	20.00	100%	50%	50%
2025 Penn Bowl - Online	11/08/25	Y	2	15.00	100%	50%	0%
2025 Penn Bowl - Ottawa	11/01/25	Y	7	17.14	100%	57%	14%
2025 Penn Bowl - UK	11/01/25	Y	9	12.22	100%	22%	0%
2025 Penn Bowl - UNC	11/01/25	Y	3	13.33	100%	33%	0%
2025 Penn Bowl - WashU	11/01/25	Y	2	25.00	100%	100%	50%

Data


RIT	Brandeis	0	0	10	10
Brown	Yale	10	0	10	20
CWRU	Michigan B	10	10	10	30
Ohio State A	Michigan C	0	0	10	10
Pittsburgh	Ohio State B	10	0	10	20
Columbia A	JHU A	0	10	10	20
Maryland C	Columbia B	0	0	10	10
Swarthmore	Maryland A	0	0	10	10
JHU B	Maryland B	0	0	10	10
Mount Sinai	John Jay	10	10	10	30
NYU A	NYU B	10	10	10	30
Texas A	Central Oklahoma	0	0	10	10
Texas B	Oklahoma	10	10	10	30
New Young Whigs of America	Wake Up Paddington A Washington Mystery	10	0	10	20
abg academy	rusty shackleford	0	0	10	10
Burnaburiash's Lapis Lazuli	1. Wawa 2. Blank Street 151. Black Sheep at Kings Cross rail	10	0	10	20
Washed Scrubs	Galactic Ombudsmen	10	0	10	20
Chimp Brisket	Of Mice and Penn	0	0	10	10
Knorr Stock Clue	Paul Quifford, or, It Was a Dark and Stormy Tournament	0	0	10	10
Penn and the Art of Tossup-Bonus cycle Maintenance	Coughing Baby	0	0	10	10
The Bit and the Penndulum	Bristold	0	0	10	10
To buzz is to be perceived	Hail to the Sheaf	0	0	10	10
Quiztian Bale in Ratman Begins	question mark	0	0	10	10
why is it called a score clue if nobody scores points on it	Alas poor Warwick, I knew him Edinburgh	0	0	10	10
VT B	UNC B	0	0	10	10
VT A	Planck Sinatra	10	0	10	20
UNC A	Wise Duke	0	0	10	10
Truman State	WashU Kiki	10	0	10	20
WashU Bouba	VJ Edgecombe School of Interior Design - Edwardsville	10	10	10	30
Waterloo you are crooked	Carleton A	10	0	10	20
Toronto Murder on the Rider Express	McGill B	0	0	10	10
McGill Fartlets	Queen's is monitoring the situation	10	0	10	20
Ottawa 67s	#OpenToBuzz	0	0	10	10
Guelph perfomative male competition	Toronto E	0	0	10	10
Toronto Operation PBSuccess	Aweille Kevin Fan osti continue comme ça	10	10	10	30
Toronto G	Toronto Sunshine Bubbles	10	0	10	20
I've been running into you in my lead plumbocene what could have benzene	Harvard	10	0	10	20
MIT A	MIT B	10	10	10	30