The causative agent of this disease contains a pE88 plasmid encoding several ABC transporters. This disease may cause Risus sardonicus and more general opisthotonus (“opp-is-THOT-uh-nuss”) also seen in cerebral palsy or strychnine poisoning. Exotoxins present in this disease include a cholesterol-dependent hemolysin and a ganglioside-binding protein that cleaves synaptobrevin. Renshaw cells are inactivated by this disease, which prevents the release of inhibitory neurotransmitters. It’s not botulism, but this disease is caused by a Clostridium bacterium and has symptoms that can be alleviated by benzodiazepines. A toxoid from this disease is included alongside diphtheria and pertussis in the Tdap vaccine. For 10 points, name this disease that causes muscle spasms associated with exposure to rusty nails. ■END■
| Northern California | Main | Y | 5 | 100% | 0% | 40% | 96.20 |
| Southern California | Main | Y | 5 | 100% | 0% | 20% | 97.60 |
| Eastern Canada | Main | Y | 12 | 100% | 0% | 17% | 95.92 |
| Florida | Main | Y | 6 | 100% | 0% | 17% | 108.33 |
| Great Lakes | Main | Y | 7 | 100% | 0% | 14% | 95.43 |
| Lower Mid-Atlantic | Main | Y | 8 | 100% | 0% | 38% | 90.00 |
| Upper Mid-Atlantic (1) | Main | Y | 10 | 100% | 0% | 20% | 96.00 |
| Upper Mid-Atlantic (2) | Main | Y | 5 | 100% | 0% | 0% | 84.00 |
| Lower Midwest | Main | Y | 4 | 100% | 0% | 25% | 88.75 |
| Upper Midwest | Main | Y | 10 | 100% | 0% | 20% | 81.40 |
| North | Main | Y | 5 | 100% | 0% | 0% | 85.80 |
| Northeast | Main | Y | 1 | 100% | 0% | 0% | 96.00 |
| Northwest | Main | Y | 4 | 100% | 0% | 50% | 104.25 |
| South Central | Main | Y | 8 | 100% | 0% | 25% | 99.00 |
| Southeast | Main | Y | 8 | 100% | 0% | 38% | 88.75 |
| UK | Main | Y | 3 | 100% | 0% | 67% | 106.33 |
| Upstate NY | Main | Y | 4 | 100% | 0% | 0% | 103.50 |
| Player | Team | Opponent | Buzz Position | Value |
|---|---|---|---|---|
| Emily Kadolph | Virginia Tech A | Virginia B | 22 | 10 |
| Joshua Iyo " | North Carolina C | Clemson A | 47 | 10 |
| Ilyas Choukri | Virginia Tech B | Virginia A | 58 | -5 |
| Elokkin Pate-Geames | Tennessee B | Liberty C | 73 | -5 |
| Henry Turner | Clemson B | South Carolina A | 93 | 10 |
| Nick Smemoe | North Carolina B | Roanoke | 97 | -5 |
| William Edwards | Tennessee A | North Carolina A | 108 | 10 |
| Johanna Bryant | Liberty B | Tusculum | 108 | 10 |
| Dixie Lumsden | Roanoke | North Carolina B | 114 | 10 |
| Hannah Worthen | Liberty C | Tennessee B | 114 | 10 |
| Liam Rojas | Virginia A | Virginia Tech B | 114 | 10 |