Question

These cells have gained interest as immunotherapy agents because they ubiquitously express programmable receptors named K·I·Rs. These cells, whose production in the uterus increases dramatically during pregnancy, are inactivated by trophoblastic expression of HLA-E. These cells express CD16 to bind IgG antibodies in a classical example (10[1])of (10[1])ADCC. (10[1])These cells’ expression (10[1])of CD56 and (10[1])lack of CD3 or TCRs allows them to be distinguished from T cells. The “missing self” hypothesis (10[2])aims to explain why these cells target cells that don’t display (10[1])MHC class I (“one”) markers. (-5[2])These cells release granules containing (10[1]-5[1])perforin (10[2])that allow (-5[1])subsequent entry of granzymes into the target cell. (10[1])For 10 points, name these innate immune cells that recognize and destroy non-self (-5[1])cells, (-5[2])like those infected by viruses and cancer cells. ■END■ (10[4]0[10])

ANSWER: natural killer cells [or NK cells]
<Biology>
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Summary

2025 ACF Nationals04/19/2025Y2370%0%30%83.19

Buzzes

PlayerTeamOpponentBuzz PositionValue
Andrew WangIllinois ANorth Carolina A4510
Collin NadarajahWUSTL BWaterloo B4610
Moses KitakuleColumbia AWUSTL A4710
Allan LeeStanfordRutgers5010
Richard NiuCornell AMIT5310
Tony ChenToronto ANorthwestern7010
Raymond ChenToronto BIowa State7010
Teigue KellyPenn StateUC Berkeley B8110
Sinecio MoralesJohns HopkinsChicago B85-5
Rohan DalalGeorgia TechVirginia Tech85-5
Rachel FanousMichiganColumbia B90-5
Adam FineChicago AUC Berkeley A9010
James WangOttawaFlorida9110
Shiva TegullaUCFNorth Carolina B9110
Alan XieYaleBritish Columbia93-5
Karan GurazadaTexasMinnesota10110
Kevin PengCornell BWinona State114-5
Isaac MammelMarylandIllinois B115-5
Michael KearneyHarvardToronto C115-5
Ezra SantosChicago BJohns Hopkins12410
Amogh KulkarniGeorgia StateArizona State12410
Bryan UgazArizona StateGeorgia State1240
Orion KellerVirginia TechGeorgia Tech1240
Liam KusalikWaterloo AIndiana12410
Shardul ParthasarathyIllinois BMaryland1240
Olin BoseColumbia BMichigan1240
Andy HuffLSENYU1240
Ryan RosenbergNYULSE1240
Cade ReinbergerRITVanderbilt1240
Gavin MarkoffVanderbiltRIT1240
Jason ZhangToronto CHarvard1240
Henry BonWinona StateCornell B12410
Russell NipBritish ColumbiaYale1240