Question
These cells have gained interest as immunotherapy agents because they ubiquitously express programmable receptors named K·I·Rs. These cells, whose production in the uterus increases dramatically during pregnancy, are inactivated by trophoblastic expression of HLA-E. These cells express CD16 to bind IgG antibodies in a classical example of ADCC. These cells’ expression of CD56 and lack of CD3 or TCRs allows them to be distinguished from T cells. The “missing self” hypothesis aims to explain why these cells target cells that don’t display MHC class I (“one”) markers. These cells release granules containing perforin that allow subsequent entry of granzymes into the target cell. For 10 points, name these innate immune cells that recognize and destroy non-self cells, like those infected by viruses and cancer cells. ■END■
Summary
2025 ACF Nationals | 04/19/2025 | Y | 23 | 70% | 0% | 30% | 83.19 |
Buzzes
Player | Team | Opponent | Buzz Position | Value |
---|---|---|---|---|
Andrew Wang | Illinois A | North Carolina A | 45 | 10 |
Collin Nadarajah | WUSTL B | Waterloo B | 46 | 10 |
Moses Kitakule | Columbia A | WUSTL A | 47 | 10 |
Allan Lee | Stanford | Rutgers | 50 | 10 |
Richard Niu | Cornell A | MIT | 53 | 10 |
Tony Chen | Toronto A | Northwestern | 70 | 10 |
Raymond Chen | Toronto B | Iowa State | 70 | 10 |
Teigue Kelly | Penn State | UC Berkeley B | 81 | 10 |
Sinecio Morales | Johns Hopkins | Chicago B | 85 | -5 |
Rohan Dalal | Georgia Tech | Virginia Tech | 85 | -5 |
Rachel Fanous | Michigan | Columbia B | 90 | -5 |
Adam Fine | Chicago A | UC Berkeley A | 90 | 10 |
James Wang | Ottawa | Florida | 91 | 10 |
Shiva Tegulla | UCF | North Carolina B | 91 | 10 |
Alan Xie | Yale | British Columbia | 93 | -5 |
Karan Gurazada | Texas | Minnesota | 101 | 10 |
Kevin Peng | Cornell B | Winona State | 114 | -5 |
Isaac Mammel | Maryland | Illinois B | 115 | -5 |
Michael Kearney | Harvard | Toronto C | 115 | -5 |
Ezra Santos | Chicago B | Johns Hopkins | 124 | 10 |
Amogh Kulkarni | Georgia State | Arizona State | 124 | 10 |
Bryan Ugaz | Arizona State | Georgia State | 124 | 0 |
Orion Keller | Virginia Tech | Georgia Tech | 124 | 0 |
Liam Kusalik | Waterloo A | Indiana | 124 | 10 |
Shardul Parthasarathy | Illinois B | Maryland | 124 | 0 |
Olin Bose | Columbia B | Michigan | 124 | 0 |
Andy Huff | LSE | NYU | 124 | 0 |
Ryan Rosenberg | NYU | LSE | 124 | 0 |
Cade Reinberger | RIT | Vanderbilt | 124 | 0 |
Gavin Markoff | Vanderbilt | RIT | 124 | 0 |
Jason Zhang | Toronto C | Harvard | 124 | 0 |
Henry Bon | Winona State | Cornell B | 124 | 10 |
Russell Nip | British Columbia | Yale | 124 | 0 |