They’re not dehydratases, but a family of enzymes that acts on this functional group frequently contains a 7-stranded antiparallel beta sheet wrapped around a 5-turn alpha helix, forming a HotDog domain. This functional group is hydrolyzed by the ACOT family of enzymes. During fatty acid and polyketide synthesis, the growing chain is linked to ACP via this functional group. A SEA group undergoes an acyl (“ASS-il”) shift to form a peptide-linked example of this functional group in situ in a variant of native chemical ligation. Citrate synthase hydrolyzes this group after binding to oxaloacetate in the first step of the Krebs cycle. Coenzyme A is often linked to fatty acids via this functional group. For 10 points, name this functional group consisting of a sulfur atom linking an acyl (“ASS-il”) group and an R group. ■END■
| 2025 ACF Nationals | 04/19/2025 | Y | 21 | 52% | 0% | 62% | 116.91 |
| Player | Team | Opponent | Buzz Position | Value |
|---|---|---|---|---|
| Aiden Dartley | Rutgers | Illinois A | 58 | 10 |
| Alex Akridge | Indiana | Florida | 58 | -5 |
| Yashwanth Bajji | Michigan | WUSTL B | 58 | -5 |
| Russell Nip | British Columbia | Minnesota | 58 | -5 |
| Bryan Ugaz | Arizona State | Texas | 58 | 10 |
| James Wang | Ottawa | LSE | 63 | -5 |
| Caleb Ott | Waterloo B | North Carolina B | 86 | -5 |
| Ryan Sun | UC Berkeley B | Northwestern | 100 | -5 |
| Shiva Tegulla | UCF | Georgia State | 106 | -5 |
| Allan Lee | Stanford | Virginia Tech | 108 | 10 |
| Richard Niu | Cornell A | Vanderbilt | 109 | -5 |
| Calvin Bostleman | Ohio State | Johns Hopkins | 112 | -5 |
| Derek Chen | Columbia B | Toronto A | 112 | -5 |
| Ian Lu | Georgia Tech | UC Berkeley A | 112 | -5 |
| Joseph Chambers | Virginia | Chicago B | 124 | -5 |
| Alan Xie | Yale | Iowa State | 130 | -5 |
| Joy An | Harvard | North Carolina A | 132 | 10 |
| Matt Schiavone | Northwestern | UC Berkeley B | 132 | 10 |
| Ezra Santos | Chicago B | Virginia | 133 | 0 |
| Julian Bushlow | Cornell B | Illinois B | 133 | 0 |
| Tiffany Zhou | Florida | Indiana | 133 | 0 |
| June Yin | WUSTL B | Michigan | 133 | 10 |
| Foster Hughes | Minnesota | British Columbia | 133 | 10 |
| Ryan Rosenberg | NYU | RIT | 133 | 10 |
| Cade Reinberger | RIT | NYU | 133 | 0 |
| Maximilian Niebur | Johns Hopkins | Ohio State | 133 | 0 |
| Tony Chen | Toronto A | Columbia B | 133 | 10 |
| Jason Zhang | Toronto C | Penn State | 133 | 0 |
| Teigue Kelly | Penn State | Toronto C | 133 | 0 |
| Rohan Shelke | UC Berkeley A | Georgia Tech | 133 | 10 |
| Amogh Kulkarni | Georgia State | UCF | 133 | 0 |
| Soren Heydari | North Carolina B | Waterloo B | 133 | 0 |
| Adam Fine | Chicago A | Winona State | 133 | 0 |
| Conor Thompson | Iowa State | Yale | 133 | 10 |