Enzymes hydrolyzing these compounds are categorized as “retaining” or “inverting,” depending on whether one of its two catalytic carboxylates displays nucleophilicity. The transition-state analog Zanamivir mimics one of these compounds, allowing the drug to inhibit neuraminidase (“nur-ah-MIN-ah-dayz”) activity during influenza infections. In one process, these compounds link to a different larger molecule at N-X-S/T (“N-X-S-slash-T”) sequences. A gradient of one of these compounds is often used to separate macromolecules during (*) centrifugation. One form of these molecules containing a free aldehyde can be detected by Benedict’s reagent. These compounds, which can be visualized using Haworth projections, are typically identified with the suffix -ose (“O-S-E”). For 10 points, name these compounds that include mannose and glucose. ■END■
ANSWER: carbohydrates [accept saccharides or sugars; accept monosaccharides or disaccharides or polysaccharides or oligosaccharides; accept glycosides; accept glycans; accept uronic acids; accept aldoses; accept ketoses; accept hexoses; accept pentoses; prompt on sucrose with “sucrose is an example of what kind of compound?”; prompt on N-acetylneuraminic acid or Neu5Ac or NANA; prompt on sialic acids]
<Kane Nguyen, Chemistry>
= Average correct buzz position