Question

The J-domain of a protein from this virus is critical for fibroblast cell lines to overcome p130/p107 repression and mediates binding with Hsc70. Carboxy-terminal residues on a protein from this virus redundantly control its binding to the innate inhibitor of WAF-1. Since that protein from this virus binds importin-alpha, it is used as a model protein to study nuclear localization signals. (15[1])Residues 106 to 114 on a protein from this virus contain a key L-X-C-X-E motif that regulates its binding to (*) retinoblastoma protein. The malignant transforming activity (-5[1])of that (-5[1])helicase from this virus has led to its usage in lentiviral cell immortalization kits since it inactivates p53. In the 1950s, this virus was identified as a contaminant in multiple polio vaccines. For 10 points, name this polyomavirus whose namesake large T antigen was first collected from a culture (-5[1])of (10[1])infected monkey (10[1])kidney (-5[1])cells. (0[1]) (10[1]0[10])■END■

ANSWER: SV40 [or simian vacuolating virus 40 or simian virus 40] (The first clue describes the J-domain’s role in binding the pRb/E2F complex. The second clue is about LTA’s interaction with p53.)
<RH, Biology>
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Summary

2024 Chicago Open07/28/2024Y1136%9%36%120.25

Buzzes

PlayerTeamOpponentBuzz PositionValue
Eric MukherjeeLMM's LLM MLMCharlotte's Moderately Successful Team6015
Rohan Khervar merchantsLying on a Mattress at Lou’s Apartment in Pilsen, Chicago86-5
Jason HongThe Jeam TeamI’ll take a quiet 10 / A handshake of CO (Chicago Open)88-5
Aseem Keyalsticking out your guyot for the ridge push; you're so seafloor spread, you're so fracture zoneNJTRANSit (and bobby, i guess)137-5
Richard YugenAI this, genAI that, have you found your 真爱 yetwhen you look this good, you don’t have to know anything13810
Billy BusseBHSU BNJTRANSit (and anwen, I guess)14010
Swapnil Gargit's the great pumpkinification objection, charlie brownThere are buzzable clues everywhere for those with eyes to see141-5
Daniel MaThere are buzzable clues everywhere for those with eyes to seeit's the great pumpkinification objection, charlie brown1420
Alex AkridgeWe Need New NamesGalvanized Square Steen and Eco-Friendly Wood Vermeer1430
Ethan AshbrookGalvanized Square Steen and Eco-Friendly Wood VermeerWe Need New Names1430
Kenji ShimizuI’ll take a quiet 10 / A handshake of CO (Chicago Open)The Jeam Team1430
Richard NiuAMOGH QUIZ HACK? 英雄联盟 400 PPG 24 TUHMindgoblin of Little Hobbes14310
Jim FanMindgoblin of Little HobbesAMOGH QUIZ HACK? 英雄联盟 400 PPG 24 TUH1430
Matt WeinerSAYYID QUTB, DRIVING THE LONGEST CAR YOU’VE EVER SEEN THROUGH TAHRIR SQUARELisan al-Quib1430
Natan HoltzmanLisan al-QuibSAYYID QUTB, DRIVING THE LONGEST CAR YOU’VE EVER SEEN THROUGH TAHRIR SQUARE1430
Jerry VinokurovThe Oldest Men in the WorldBerkeley Mafia and the Chicago Boy1430
Michael CoatesBerkeley Mafia and the Chicago BoyThe Oldest Men in the World1430
Sky HongNJTRANSit (and bobby, i guess)sticking out your guyot for the ridge push; you're so seafloor spread, you're so fracture zone1430
Victor PavaoLying on a Mattress at Lou’s Apartment in Pilsen, Chicagovar merchants1430