Question
In one pathway partly named for this protein, MMB complexes binding onto CHR elements are replaced with DREAM complexes. E6-associated protein ligase tags this protein for degradation during infections of certain strains of human papillomavirus. A mutation in this protein causes Li–Fraumeni syndrome. Phosphorylation of this protein by ATM prevents it from being ubiquitinated by (*) Mdm2. This protein directly induces the CDK inhibitor, p21. The binding of this protein to DNA damage initiates cell cycle arrest at the G1/S checkpoint. Deletions and mutations of this protein are responsible for over half of all human cancers. For 10 points, name this tumor suppressor colloquially known as the “guardian of the genome.” ■END■
ANSWER: p53 [or TP53; accept transformation-related protein P53; accept TRP53; accept p53-DREAM pathway; accept p21 before “E6-associated” is read]
<Science - Biology>
= Average correct buzz position
Buzzes
Player | Team | Opponent | Buzz Position | Value |
---|---|---|---|---|
Tianyu Xu | Georgia Tech A | Georgia Tech C | 72 | 10 |
Kevin Park | Claremont | MTSU | 94 | 10 |
Jeremy Cummings | WUSTL | USN A | 94 | -5 |
Matthew Sumanen | Georgia Tech B | Belmont | 97 | -5 |
Jack Lewis | MTSU | Georgia Tech B | 107 | 10 |
Allie Bennett | Belmont | Georgia Tech B | 110 | 0 |
Gavin Markoff | Vanderbilt A | Vanderbilt B | 110 | 10 |
Summary
2024 Booster Shot (Columbia) | 02/23/2024 | Y | 6 | 50% | 0% | 67% | 107.00 |
2024 Booster Shot (Waterloo) | 02/23/2024 | Y | 4 | 100% | 25% | 0% | 74.25 |
2024 Booster Shot (Vanderbilt) | 03/02/2024 | Y | 5 | 60% | 0% | 40% | 92.00 |
2024 Booster Shot (Vanderbilt) | 03/02/2024 | Y | 1 | 100% | 0% | 0% | 107.00 |
2024 Booster Shot (Great Lakes) | 03/09/2024 | Y | 4 | 100% | 25% | 0% | 85.00 |
2024 Booster Shot (WUSTL) | 03/09/2024 | Y | 3 | 67% | 67% | 0% | 40.00 |