Question

In one pathway partly named for this protein, MMB complexes binding onto CHR elements are replaced with DREAM complexes. E6-associated protein ligase tags this protein for degradation during infections of certain strains of human papillomavirus. A mutation in this protein causes Li–Fraumeni syndrome. Phosphorylation of this protein by ATM prevents it from being ubiquitinated by (*) Mdm2. This protein directly induces the CDK inhibitor, p21. The binding of this protein to DNA damage (10[1])initiates cell cycle arrest at the G1/S checkpoint. Deletions and mutations of this protein are responsible for over half of all human (10[1]-5[1])cancers. For 10 (-5[1])points, name this tumor suppressor colloquially known as the “guardian (10[1])of the genome.” (10[1]0[1])■END■

ANSWER: p53 [or TP53; accept transformation-related protein P53; accept TRP53; accept p53-DREAM pathway; accept p21 before “E6-associated” is read]
<Science - Biology>
= Average correct buzz position

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Buzzes

PlayerTeamOpponentBuzz PositionValue
Tianyu XuGeorgia Tech AGeorgia Tech C7210
Kevin ParkClaremontMTSU9410
Jeremy CummingsWUSTLUSN A94-5
Matthew SumanenGeorgia Tech BBelmont97-5
Jack LewisMTSUGeorgia Tech B10710
Allie BennettBelmontGeorgia Tech B1100
Gavin MarkoffVanderbilt AVanderbilt B11010

Summary

2024 Booster Shot (Columbia)02/23/2024Y650%0%67%107.00
2024 Booster Shot (Waterloo)02/23/2024Y4100%25%0%74.25
2024 Booster Shot (Vanderbilt)03/02/2024Y560%0%40%92.00
2024 Booster Shot (Vanderbilt)03/02/2024Y1100%0%0%107.00
2024 Booster Shot (Great Lakes)03/09/2024Y4100%25%0%85.00
2024 Booster Shot (WUSTL)03/09/2024Y367%67%0%40.00