In one pathway partly named for this protein, MMB complexes binding onto CHR elements are replaced with DREAM complexes. E6-associated protein ligase tags this protein for degradation during infections of certain strains of human papillomavirus. A mutation in this protein causes Li–Fraumeni syndrome. Phosphorylation of this protein by ATM prevents it from being ubiquitinated by (*) Mdm2. This protein directly induces the CDK inhibitor, p21. The binding of this protein to DNA damage (10[1])initiates cell cycle arrest at the G1/S checkpoint. Deletions and mutations of this protein are responsible for over half of all human (10[1]-5[1])cancers. For 10 (-5[1])points, name this tumor suppressor colloquially known as the “guardian (10[1])of the genome.” (10[1]0[1])■END■