Question

In one pathway partly named for this protein, MMB complexes binding onto CHR elements are replaced with DREAM complexes. E6-associated protein ligase (15[1])tags (-5[1])this protein for (-5[1])degradation during infections (15[1])of certain strains of human papillomavirus. A mutation in (15[1])this protein causes Li–Fraumeni (15[1])syndrome. Phosphorylation of this protein by ATM prevents it from being (-5[1])ubiquitinated by (*) Mdm2. This protein directly induces the CDK inhibitor, p21. The binding of this protein to DNA damage (10[1])initiates cell cycle arrest at the (10[1])G1/S checkpoint. Deletions and mutations of this protein are (10[1])responsible for over half of all human (10[1]-5[1])cancers. For 10 (-5[1])points, (10[1])name this tumor (10[1]-5[1])suppressor colloquially known (10[1])as the “guardian (10[1])of the (10[1])genome.” (10[4]0[5])■END■

ANSWER: p53 [or TP53; accept transformation-related protein P53; accept TRP53; accept p53-DREAM pathway; accept p21 before “E6-associated” is read]
<Science - Biology>
= Average correct buzz position

Summary

2024 Booster Shot (Columbia)02/23/2024Y650%0%67%107.00
2024 Booster Shot (Waterloo)02/23/2024Y4100%25%0%74.25
2024 Booster Shot (Vanderbilt)03/02/2024Y560%0%40%92.00
2024 Booster Shot (Vanderbilt)03/02/2024Y1100%0%0%107.00
2024 Booster Shot (Great Lakes)03/09/2024Y4100%25%0%85.00
2024 Booster Shot (WUSTL)03/09/2024Y367%67%0%40.00

Buzzes

PlayerTeamOpponentBuzz PositionValue
Raymond ChenToronto Penguin World WarToronto Tony Jingyu Chen eats quizbowl2215
Moses KitakuleColumbia BColumbia C23-5
Andrew MinagarYaleColumbia A26-5
Annabelle YangWUSTLStanford2915
Amith PunyalaWUSTL AWUSTL J3815
Collin NadarajahWUSTL CSquidward Community College4215
Kushal AluruRutgersNYU A53-5
Tianyu XuGeorgia Tech AGeorgia Tech C7210
Liam KusalikWaterloo CaliToronto Pilk7810
Jason ZhangToronto cDNAWaterloo Bust8710
Kevin ParkClaremontMTSU9410
Jeremy CummingsWUSTLUSN A94-5
Matthew SumanenGeorgia Tech BBelmont97-5
Pranav SivaramOhioCase Western9810
Austin GuoPrincetonBard101-5
Claire WilsonLehigh BNYU B10110
Conor ThompsonIowa StateNorth Carolina10410
Jack LewisMTSUGeorgia Tech B10710
Abigail ZimmermanIowaPenn State B10910
Evan SchleckGathererLehigh A1100
Eddie FuhrerLehigh AGatherer1100
Derek ChenColumbia AYale11010
Eshan PantNYU ARutgers11010
Allie BennettBelmontGeorgia Tech B1100
Gavin MarkoffVanderbilt AVanderbilt B11010
Fred GarveyTruman StateSIUE1100
Logan MathisSIUETruman State1100
Amy WangToronto SproutOttawa11010