In one pathway partly named for this protein, MMB complexes binding onto CHR elements are replaced with DREAM complexes. E6-associated protein ligase (15[1])tags (-5[1])this protein for (-5[1])degradation during infections (15[1])of certain strains of human papillomavirus. A mutation in (15[1])this protein causes Li–Fraumeni (15[1])syndrome. Phosphorylation of this protein by ATM prevents it from being (-5[1])ubiquitinated by (*) Mdm2. This protein directly induces the CDK inhibitor, p21. The binding of this protein to DNA damage (10[1])initiates cell cycle arrest at the (10[1])G1/S checkpoint. Deletions and mutations of this protein are (10[1])responsible for over half of all human (10[1]-5[1])cancers. For 10 (-5[1])points, (10[1])name this tumor (10[1]-5[1])suppressor colloquially known (10[1])as the “guardian (10[1])of the (10[1])genome.” (10[4]0[5])■END■