Question
This technique is followed by hit to lead and lead optimization. For 10 points each:
[10m] Name this technique, where a robot arm pipets nanoliters of liquid from stock microtiter plates onto assay plates to search through thousands of molecules of pharmaceutical interest.
ANSWER: high-throughput screening [or HTS]
[10h] Drug discovery commonly uses high-throughput screening and QSAR models, whose predictors are these things. In cheminformatics, these things are the quantities generated from the symbolic representation of a molecule.
ANSWER: molecular descriptors
[10e] Demis Hassabis and John Jumper won the 2024 Nobel Prize in Chemistry for their work on predicting the results of this process, which has applications in drug discovery. This process can result in secondary structures like alpha helices and beta sheets.
ANSWER: protein folding [accept Alphafold]
<Science - Chemistry>
Summary
| 2024 ARGOS @ Brandeis | 03/22/2025 | Y | 3 | 10.00 | 100% | 0% | 0% |
| 2024 ARGOS @ Chicago | 11/23/2024 | Y | 6 | 13.33 | 100% | 33% | 0% |
| 2024 ARGOS @ Christ's College | 12/14/2024 | Y | 3 | 6.67 | 67% | 0% | 0% |
| 2024 ARGOS @ Columbia | 11/23/2024 | Y | 3 | 10.00 | 100% | 0% | 0% |
| 2024 ARGOS @ McMaster | 11/17/2024 | Y | 5 | 18.00 | 100% | 80% | 0% |
| 2024 ARGOS @ Stanford | 02/22/2025 | Y | 3 | 20.00 | 100% | 67% | 33% |
| 2024 ARGOS Online | 03/22/2025 | Y | 3 | 10.00 | 100% | 0% | 0% |
Data
| Simpson Agonistes: The Crisis of Donut | Communism is Soviet power plus the yassification of the whole country | 10 | 0 | 10 | 20 |
| The Only Existing Manuscript from A Clockwork Orange | Moderator Can't Neg me While in Alpha | 10 | 0 | 10 | 20 |
| I'd prefer to have the team name be Christensen et al. than anything that Erik cooks up | Ryan Wesley Routh's 10 000 NATO-trained Afghan Quizbowlers | 10 | 0 | 10 | 20 |
| Tensei Shitara Flashcard Data Ken | She Dicer On My Argonaute Till I RNA Interfere | 0 | 0 | 10 | 10 |
| You cannot go to Aarhus to see his peat-brown head / With eyes like ripening fruit | as rational as the square root of two power bottoms | 10 | 0 | 10 | 20 |