high-throughput screening - 2024 ARGOS

Question

This technique is followed by hit to lead and lead optimization. For 10 points each:

[10m] Name this technique, where a robot arm pipets nanoliters of liquid from stock microtiter plates onto assay plates to search through thousands of molecules of pharmaceutical interest.

ANSWER: high-throughput screening [or HTS]

[10h] Drug discovery commonly uses high-throughput screening and QSAR models, whose predictors are these things. In cheminformatics, these things are the quantities generated from the symbolic representation of a molecule.

ANSWER: molecular descriptors

[10e] Demis Hassabis and John Jumper won the 2024 Nobel Prize in Chemistry for their work on predicting the results of this process, which has applications in drug discovery. This process can result in secondary structures like alpha helices and beta sheets.

ANSWER: protein folding [accept Alphafold]

Back to bonuses

Summary


2024 ARGOS @ Brandeis	03/22/2025	Y	3	10.00	100%	0%	0%
2024 ARGOS @ Chicago	11/23/2024	Y	6	13.33	100%	33%	0%
2024 ARGOS @ Christ's College	12/14/2024	Y	3	6.67	67%	0%	0%
2024 ARGOS @ Columbia	11/23/2024	Y	3	10.00	100%	0%	0%
2024 ARGOS @ McMaster	11/17/2024	Y	5	18.00	100%	80%	0%
2024 ARGOS @ Stanford	02/22/2025	Y	3	20.00	100%	67%	33%
2024 ARGOS Online	03/22/2025	Y	3	10.00	100%	0%	0%

Data


\|madam\|	Banned from ARGOS	0	0	10	10
Pahkin' the Ahgo	Hu up Jinning they Tao	0	0	10	10
Import Pandas	"Powers a question on Stancyzk" that's a clown question bro	0	0	10	10
BHSU Rebirth	Who is the Colleen Hoover of the Zulus?	10	0	10	20
Clown Squad	hawk two of	0	0	10	10
BHSU ReFantazio	Music to Help You Stop Smoking	10	0	10	20
Clown Senpais	Northeast by Northwestern	0	0	10	10
Notre Dame	That Feeling When Knee Surgery Is in Five Days	0	0	10	10
WashU	The Love Song of J Alfred PrufRock and Roll All Nite (and Party Every Day)	0	0	10	10
Limp Franceskit	Cambridge	0	0	0	0
Simple Vibes	Cien Años de Quizboledad	0	0	10	10
Defying Suavity	Grzegorz Brzęczyszczykiewicz	0	0	10	10
Walston et. al.	Cope is the thing with feathers	0	0	10	10
jeff mcneil #1 morningside heights fan club	12 Litres of Green Tea	0	0	10	10
just one more half-dot bro	NJ TRANSit (and anwen i guess)	0	0	10	10
Simpson Agonistes: The Crisis of Donut	Communism is Soviet power plus the yassification of the whole country	10	0	10	20
The Only Existing Manuscript from A Clockwork Orange	Moderator Can't Neg me While in Alpha	10	0	10	20
I'd prefer to have the team name be Christensen et al. than anything that Erik cooks up	Ryan Wesley Routh's 10 000 NATO-trained Afghan Quizbowlers	10	0	10	20
Tensei Shitara Flashcard Data Ken	She Dicer On My Argonaute Till I RNA Interfere	0	0	10	10
You cannot go to Aarhus to see his peat-brown head / With eyes like ripening fruit	as rational as the square root of two power bottoms	10	0	10	20
Stanford+	Cry of the Common Loon	10	0	10	20
Where are the ACF Nationals recordings?	A is for Amy Robsart who fell down the stairs	0	0	10	10
number of tang poems = 75 times number of lines in a shi = 100 times number of lines in a haiku	Berkeley	10	10	10	30
throw away your cards, rally in the streets	I wish it were possible to freeze time so I would never have to watch you retire	0	0	10	10
Thompson et al.	CLEVELAND, THIS IS FOR YOU!	0	0	10	10
Aw we're so sorry to hear that maman died today, she gets five big booms	UBC	0	0	10	10